Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.32 |
| ▸ | WNT3A | P56704 | 3/20 | 0.32 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | WNT1 | P04628 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | PRKACA | P17612 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5309402 | 0.91 | CA12 (0.37) | MAPK14JAK2MEN1KMT2AKDM4E | |
| SCHEMBL5309338 | 0.86 | IRAK4 (0.38) | APOBEC3AAPOBEC3GAURKAKDM5BMEN1 | |
| SCHEMBL5306834 | 0.85 | PDE4A (0.37) | APOBEC3AAPOBEC3GAURKADAPK3JAK2 | |
| SCHEMBL5312693 | 0.85 | APOBEC3A (0.35) | KMOAPOBEC3AAPOBEC3GAURKADAPK3 | |
| SCHEMBL5310044 | 0.85 | MEN1 (0.39) | APOBEC3AAPOBEC3GAURKADAPK3JAK2 | |
| SCHEMBL5309593 | 0.85 | HPGD (0.39) | APOBEC3AAPOBEC3GAURKAMAP4K4MEN1 | |
| SCHEMBL5310626 | 0.83 | ALKBH5 (0.36) | APOBEC3AAPOBEC3GKDM2BKDM4C | |
| SCHEMBL5306949 | 0.82 | APOBEC3A (0.38) | APOBEC3AAPOBEC3GKDM5BMEN1KMT2A | |
| SCHEMBL5312653 | 0.81 | APOBEC3A (0.35) | APOBEC3AAPOBEC3GNTRK1MEN1KMT2A | |
| SCHEMBL5309825 | 0.81 | IRAK4 (0.36) | APOBEC3AAPOBEC3GAURKADAPK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007039146-A1 | 4-CARBOXY PYRAZOLE DERIVATIVES AS ANTI-VIRAL AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-12 | — | — | WO | claimed |
| WO-2007039146-A1 | 4-CARBOXY PYRAZOLE DERIVATIVES AS ANTI-VIRAL AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-12 | — | — | WO | disclosed |
| WO-2007039146-A1 | 4-CARBOXY PYRAZOLE DERIVATIVES AS ANTI-VIRAL AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-12 | — | — | WO | disclosed |