Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.57 |
| ▸ | RAB9A | P51151 | 8/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | ACR | P10323 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | STAT1 | P42224 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.49 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.46 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5312131 | 1.00 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL5312654 | 1.00 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL5316897 | 0.83 | RAB9A (0.58) | NPC1RAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL5314689 | 0.81 | HPGD (0.65) | NPC1RAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL14160558 | 0.79 | ACR (0.53) | NPC1RAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL5314118 | 0.78 | HPGD (0.58) | NPC1RAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL4093700 | 0.78 | ALDH1A1 (0.66) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL14160551 | 0.77 | TRPV1 (0.70) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL5375870 | 0.76 | ACR (0.58) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL14160552 | 0.76 | TP53 (0.58) | NPC1RAB9ASMN1; SMN2HTTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007067710-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS FOR MODULATING TRPV1 | AMPHORA DISCOVERY CORPORATION (US) | 2007-06-14 | — | — | WO | claimed |
| WO-2007067710-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS FOR MODULATING TRPV1 | AMPHORA DISCOVERY CORPORATION (US) | 2007-06-14 | — | — | WO | disclosed |