Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.58 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 5/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.39 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5311595 | 0.87 | ACHE (0.44) | HSP90AB1ACHE | |
| SCHEMBL5313087 | 0.81 | GRM2 (0.52) | GRM2HDAC6HDAC1 | |
| SCHEMBL31006527 | 0.80 | HSP90AB1 (0.76) | HSP90AB1ACHEL3MBTL1METAP2GRM2 | |
| SCHEMBL29283806 | 0.80 | HSP90AB1 (0.76) | HSP90AB1ACHEL3MBTL1METAP2GRM2 | |
| SCHEMBL582811 | 0.80 | HSP90AB1 (0.61) | HSP90AB1ACHEL3MBTL1METAP2GRM2 | |
| SCHEMBL28189599 | 0.79 | HSP90AB1 (0.59) | HSP90AB1ACHEL3MBTL1METAP2GRM2 | |
| SCHEMBL5311119 | 0.78 | FLT3 (0.45) | L3MBTL1GRM2HDAC6HDAC1KDM4E | |
| SCHEMBL5310274 | 0.78 | HTR6 (0.43) | GRM2HDAC6HDAC1 | |
| SCHEMBL5314964 | 0.78 | RXFP1 (0.41) | HSP90AB1GRM2PSMB1PSMB5PSMB2 | |
| SCHEMBL5316623 | 0.78 | CYP19A1 (0.42) | ACHEL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007053352-A2 | PYRROLOQUINOLINONE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2007-05-10 | — | — | WO | disclosed |
| US-20070099911-A1 | Pyrroloquinolinone derivatives as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099911-A1 | Pyrroloquinolinone derivatives as 5-hydroxytryptamine-6 ligands | HTR6, HTR5A, HTR2C | HSP90AB1 2026/4885ACHE 706/4885L3MBTL1 4551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.