Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 11/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5308632 | 0.89 | HDAC3 (0.48) | GRM2HDAC3HDAC1HDAC6TNF | |
| SCHEMBL5311119 | 0.88 | FLT3 (0.45) | GRM2HDAC3HDAC1HDAC6TNF | |
| SCHEMBL5314964 | 0.85 | RXFP1 (0.41) | GRM2HDAC3HDAC1HDAC6TNF | |
| SCHEMBL5310274 | 0.85 | HTR6 (0.43) | GRM2HDAC3HDAC1HDAC6GRM4 | |
| SCHEMBL5312433 | 0.81 | HSP90AB1 (0.58) | GRM2HDAC1HDAC6 | |
| SCHEMBL5308849 | 0.80 | CHEK1 (0.42) | EGFRPOLBCHEK1FLT3GRM4 | |
| SCHEMBL5311595 | 0.78 | ACHE (0.44) | POLB | |
| SCHEMBL5311724 | 0.78 | FLT3 (0.50) | GRM2POLBCHEK1FLT3GRM4 | |
| SCHEMBL6923560 | 0.78 | GRM2 (0.55) | GRM2HDAC3HDAC1HDAC6TNF | |
| SCHEMBL5309410 | 0.76 | ALDH1A1 (0.43) | GRM2HDAC3HDAC1HDAC6GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007053352-A2 | PYRROLOQUINOLINONE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2007-05-10 | — | — | WO | disclosed |
| US-20070099911-A1 | Pyrroloquinolinone derivatives as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099911-A1 | Pyrroloquinolinone derivatives as 5-hydroxytryptamine-6 ligands | HTR6, HTR5A, HTR2C | GRM2 62/4885HDAC3 2042/4885HDAC1 2479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.