Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.46 |
| ▸ | FEN1 | P39748 | 2/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2975919 | 0.93 | LMNA (0.57) | LMNASMN1; SMN2MAPK1RAB9ATDP1 | |
| SCHEMBL2969574 | 0.89 | ALOX5AP (0.54) | SMN1; SMN2MEN1KMT2AALOX5APFEN1 | |
| SCHEMBL16501314 | 0.77 | ALDH1A1 (0.65) | LMNASMN1; SMN2MEN1KMT2AALOX5AP | |
| SCHEMBL15660683 | 0.76 | ALDH1A1 (0.64) | LMNASMN1; SMN2MAPK1VCAM1MEN1 | |
| SCHEMBL27652442 | 0.73 | MCOLN3 (0.49) | LMNASMN1; SMN2MAPK1RAB9ATDP1 | |
| SCHEMBL2061369 | 0.72 | PKM (0.76) | LMNASMN1; SMN2VCAM1MEN1KMT2A | |
| SCHEMBL1472314 | 0.72 | LMNA (0.59) | LMNASMN1; SMN2MAPK1RAB9ATDP1 | |
| SCHEMBL12339098 | 0.71 | GAA (0.54) | LMNASMN1; SMN2MAPK1TDP1VCAM1 | |
| SCHEMBL18455304 | 0.71 | NFKBIA (0.49) | LMNAMAPK1TDP1KMT2AALDH1A1 | |
| SCHEMBL8337970 | 0.71 | VCAM1 (0.73) | LMNARAB9AVCAM1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802586-A2 | HETEROARYL-SUBSTITUTED ALKYNE COMPOUNDS AND METHOD OF USE | Amgen Inc. (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006044823-A2 | HETEROARYL-SUBSTITUTED ALKYNE COMPOUNDS AND METHOD OF USE | AMGEN INC. (US) | 2006-04-27 | — | — | WO | disclosed |