Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 1/20 | 0.42 |
| ▸ | PYGM | P11217 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 7/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 6/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CALCRL | Q16602 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23532179 | 0.86 | CRBN (0.49) | PYGLPYGMRIPK1CRBNIDH1 | |
| SCHEMBL29619167 | 0.82 | EPHX2 (0.49) | PYGLPYGMRIPK1CRBNIDH1 | |
| SCHEMBL8273799 | 0.82 | EPHX2 (0.49) | PYGLPYGMRIPK1CRBNIDH1 | |
| SCHEMBL21496629 | 0.78 | RIPK1 (0.62) | RIPK1 | |
| SCHEMBL21496628 | 0.78 | RIPK1 (0.62) | RIPK1 | |
| SCHEMBL5311229 | 0.78 | RIPK1 (0.45) | PYGLPYGMRIPK1CRBNGSK3B | |
| SCHEMBL29900499 | 0.77 | PYGL (0.64) | PYGLPYGMRIPK1 | |
| SCHEMBL25329367 | 0.77 | PYGL (0.64) | PYGLPYGMRIPK1 | |
| SCHEMBL15541576 | 0.77 | PYGL (0.64) | PYGLPYGMRIPK1 | |
| SCHEMBL19866124 | 0.76 | RIPK1 (0.64) | RIPK1CRBNGSK3BCALCRL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758863-A1 | TETRAHYDROQUINOLONES AND AZA-ANALOGUES THEREOF FOR USE AS DPP-IV INHIBITORS IN THE TREATEMENT OF DIABETES | AstraZeneca AB (SE) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123685-A1 | TETRAHYDROQUINOLONES AND AZA-ANALOGUES THEREOF FOR USE AS DPP-IV INHIBITORS IN THE TREATEMENT OF DIABETES | ASTRAZENECA AB (SE) | 2005-12-29 | — | — | WO | disclosed |
| WO-2005020987-A1 | HETEROCYCLIC AMIDE DERIVATIVES WHICH POSSES GLYCOGEN PHOSPHORYLASE INHIBITORY ACTIVITY | ASTRAZENECA AB (SE) | 2005-03-10 | — | — | WO | disclosed |