Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 6/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | FPR2 | P25090 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5308221 | 0.88 | ALDH1A1 (0.42) | ABCB1HTR1ADRD2ALDH1A1FAAH | |
| SCHEMBL5313082 | 0.86 | LMNA (0.45) | ABCB1HTR1ADRD2ALDH1A1FAAH | |
| SCHEMBL5311498 | 0.86 | ALDH1A1 (0.51) | ALDH1A1FAAHGAAPKMCYP1A2 | |
| SCHEMBL5308884 | 0.83 | ALDH1A1 (0.44) | ABCB1HTR1ADRD2ALDH1A1FAAH | |
| SCHEMBL5308888 | 0.83 | ALDH1A1 (0.44) | ABCB1HTR1ADRD2ALDH1A1FAAH | |
| SCHEMBL5308868 | 0.79 | GAA (0.42) | ALDH1A1GAAPKMCYP1A2CYP3A4 | |
| SCHEMBL5311126 | 0.79 | ALDH1A1 (0.42) | ABCB1HTR1ADRD2ALDH1A1FAAH | |
| SCHEMBL5311122 | 0.79 | ALDH1A1 (0.42) | ABCB1HTR1ADRD2ALDH1A1FAAH | |
| SCHEMBL5307948 | 0.79 | CASR (0.49) | ALDH1A1GAAPKMPDE5AFPR2 | |
| SCHEMBL5307935 | 0.79 | TP53 (0.44) | ALDH1A1MAPTHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |