Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | CASR | P41180 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5313082 | 0.93 | LMNA (0.45) | ALDH1A1MEN1LMNAHTTKMT2A | |
| SCHEMBL5313176 | 0.88 | ABCB1 (0.47) | ALDH1A1HTTSMN1; SMN2ABCB1HTR1A | |
| SCHEMBL5307935 | 0.87 | TP53 (0.44) | ALDH1A1MEN1LMNAHTTKMT2A | |
| SCHEMBL5315681 | 0.86 | CASR (0.49) | ALDH1A1HTTCASRGAAPKM | |
| SCHEMBL5316086 | 0.84 | CASR (0.41) | ALDH1A1HTTCASRGRIN1GRIN2B | |
| SCHEMBL5311481 | 0.83 | ALDH1A1 (0.40) | ALDH1A1MEN1LMNAHTTKMT2A | |
| SCHEMBL5311478 | 0.83 | ALDH1A1 (0.40) | ALDH1A1MEN1LMNAHTTKMT2A | |
| SCHEMBL5312354 | 0.83 | TP53 (0.42) | ALDH1A1MEN1LMNAHTTKMT2A | |
| SCHEMBL5308342 | 0.83 | POLB (0.48) | ALDH1A1MEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL5310887 | 0.82 | LMNA (0.38) | ALDH1A1MEN1LMNAHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |