Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PRCP | P42785 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 2/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4239501 | 0.74 | AKR1C3 (0.48) | ALDH1A1KDM4ETSHRNPSR1MAPT | |
| SCHEMBL4043644 | 0.68 | MAOA (0.46) | GAAALDH1A1KDM4EPRCPTSHR | |
| SCHEMBL18351805 | 0.67 | ALDH1A1 (0.36) | GAAALDH1A1KDM4EPRCPTSHR | |
| SCHEMBL4514045 | 0.66 | TSHR (0.44) | TSHRNPSR1MAPTOPRM1KDM1A | |
| SCHEMBL21591619 | 0.65 | PRCP (0.42) | GAAPRCPOPRM1SLC22A1KDM1A | |
| SCHEMBL1952904 | 0.65 | PRCP (0.45) | GAAALDH1A1KDM4EPRCPHTR2C | |
| SCHEMBL3420659 | 0.65 | OPRM1 (0.40) | GAAALDH1A1KDM4EPRCPTSHR | |
| Hydrochloric Acid SCHEMBL4514461 | 0.65 | TSHR (0.47) | GAATSHRNPSR1MAPTOPRM1 | |
| Hydrochloric Acid SCHEMBL3878664 | 0.65 | TSHR (0.47) | GAATSHRNPSR1MAPTOPRM1 | |
| SCHEMBL5202296 | 0.64 | HTR6 (0.53) | HTR2CMAPTHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863771-A2 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS B-SECRETASE INHIBITORS | Transtech Pharma, Inc. (US) | 2007-12-12 | — | — | EP | claimed |
| WO-2006099379-A2 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS B-SECRETASE INHIBITORS | TRANSTECH PHARMA, INC. (US) | 2006-09-21 | — | — | WO | claimed |