Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 16/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5312345 | 0.99 | HSD11B1 (0.49) | HSD11B1CYP3A4CYP2C9CYP2C19GRIA2 | |
| SCHEMBL5308835 | 0.93 | CCR1 (0.40) | HSD11B1CYP3A4CYP2C9CYP2C19GRIA2 | |
| SCHEMBL5381831 | 0.92 | HSD11B1 (0.39) | HSD11B1CYP3A4CYP2C9CYP2C19GRIA2 | |
| SCHEMBL5313011 | 0.92 | ALDH1A1 (0.49) | HSD11B1CYP3A4CYP2C9CYP2C19GRIA2 | |
| SCHEMBL5313190 | 0.82 | CCR1 (0.37) | F10CCR1 | |
| SCHEMBL5362249 | 0.82 | CCR1 (0.39) | CYP2C19F10CCR1 | |
| SCHEMBL5310532 | 0.80 | F10 (0.38) | F10CCR1 | |
| SCHEMBL5379498 | 0.80 | CCR1 (0.40) | CCR1 | |
| SCHEMBL5307635 | 0.78 | CCR1 (0.39) | CCR1 | |
| SCHEMBL4458712 | 0.78 | CCR1 (0.64) | HSD11B1CYP2C19CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007073432-A2 | PIPERIDINE DERIVATIVES AND METHODS OF USE | CHEMOCENTRYX, INC. (US) | 2007-06-28 | — | — | WO | disclosed |