Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | TP53 | P04637 | 3/20 | 0.59 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | TOP1 | P11387 | 1/20 | 0.56 |
| ▸ | TOP2A | P11388 | 1/20 | 0.56 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.54 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.54 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | MDM4 | O15151 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17200812 | 0.93 | NPC1 (0.52) | NPC1KMT2AMEN1RAB9ATP53 | |
| SCHEMBL1470784 | 0.88 | NPC1 (0.73) | NPC1KMT2AMEN1RAB9ATP53 | |
| SCHEMBL4946074 | 0.88 | NPC1 (0.73) | NPC1KMT2AMEN1RAB9ATP53 | |
| SCHEMBL19630945 | 0.87 | HDAC1 (0.66) | NPC1KMT2AMEN1RAB9ATP53 | |
| SCHEMBL462324 | 0.84 | MEN1 (0.66) | NPC1KMT2AMEN1RAB9ATP53 | |
| SCHEMBL2332797 | 0.83 | KMT2A (0.77) | KMT2AMEN1RAB9APKML3MBTL1 | |
| SCHEMBL6029925 | 0.82 | NPC1 (0.82) | NPC1KMT2AMEN1RAB9ATP53 | |
| SCHEMBL3860173 | 0.80 | TOP1 (0.59) | NPC1KMT2AMEN1RAB9ATP53 | |
| SCHEMBL7817331 | 0.80 | HDAC1 (0.69) | NPC1KMT2AMEN1RAB9AKCNMA1 | |
| SCHEMBL3864321 | 0.80 | TOP1 (0.62) | NPC1KMT2AMEN1RAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070148185-A1 | Novel therapeutic target for protozoal diseases | VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY | 2007-06-28 | — | — | US | claimed |
| WO-2007047579-A2 | A NOVEL THERAPEUTIC TARGET FOR PROTOZOAL DISEASES | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2007-04-26 | — | — | WO | claimed |
| EP-2931280-B1 | METHODS AND COMPOSITIONS FOR INHIBITING CNKSR1 | PHUSIS THERAPEUTICS INC (US) | 2018-02-14 | — | — | EP | disclosed |