Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 7/20 | 0.43 |
| ▸ | PYGM | P11217 | 5/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | HTR5A | P47898 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25330404 | 0.84 | PYGL (0.42) | PYGLPYGMRIPK1DDB1CRBN | |
| SCHEMBL3948178 | 0.84 | PYGL (0.42) | PYGLPYGMBRD4RIPK1DDB1 | |
| SCHEMBL8274796 | 0.84 | EPHX2 (0.47) | PYGLPYGMCREBBPBRD4RIPK1 | |
| SCHEMBL8274775 | 0.82 | CREBBP (0.39) | PYGLPYGMCREBBPBRD4HTR5A | |
| SCHEMBL13750022 | 0.80 | NAAA (0.47) | CRBNALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL15541576 | 0.78 | PYGL (0.64) | PYGLPYGMCREBBPBRD4RIPK1 | |
| SCHEMBL29900499 | 0.78 | PYGL (0.64) | PYGLPYGMCREBBPBRD4RIPK1 | |
| SCHEMBL25329367 | 0.78 | PYGL (0.64) | PYGLPYGMCREBBPBRD4RIPK1 | |
| SCHEMBL13090959 | 0.77 | CREBBP (0.42) | CREBBPBRD4HTR5ADDB1CRBN | |
| SCHEMBL4390484 | 0.75 | PYGL (0.46) | PYGLPYGMDDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758863-A1 | TETRAHYDROQUINOLONES AND AZA-ANALOGUES THEREOF FOR USE AS DPP-IV INHIBITORS IN THE TREATEMENT OF DIABETES | AstraZeneca AB (SE) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123685-A1 | TETRAHYDROQUINOLONES AND AZA-ANALOGUES THEREOF FOR USE AS DPP-IV INHIBITORS IN THE TREATEMENT OF DIABETES | ASTRAZENECA AB (SE) | 2005-12-29 | — | — | WO | disclosed |