Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8535189 | 0.80 | KMT2A (0.68) | KMT2AL3MBTL1 | |
| SCHEMBL5313367 | 0.78 | HAO1 (0.46) | KMT2AL3MBTL1MMP2MMP9MMP8 | |
| SCHEMBL5314092 | 0.78 | GSR (0.43) | GSRKMT2AL3MBTL1MMP2MMP9 | |
| SCHEMBL5309685 | 0.77 | GSR (0.51) | GSRL3MBTL1MMP2MMP9MMP8 | |
| SCHEMBL18770314 | 0.77 | GSR (0.39) | GSRKMT2APTGS2EPHX2NR1H4 | |
| SCHEMBL27481214 | 0.76 | KMT2A (0.43) | KMT2AL3MBTL1 | |
| SCHEMBL14518760 | 0.75 | GSR (0.56) | GSRMMP2MMP9MMP8 | |
| SCHEMBL17290620 | 0.74 | PTGS2 (0.43) | GSRKMT2APTGS2 | |
| SCHEMBL19659999 | 0.73 | L3MBTL1 (0.60) | KMT2AL3MBTL1 | |
| SCHEMBL10541229 | 0.73 | GSR (0.54) | GSRKMT2AMMP2MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799823-B1 | 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses | DAIICHI SANKYO CO LTD (JP) | 2007-10-31 | — | — | EP | disclosed |
| US-RE39420-E1 | 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses | SANKYO COMPANY, LIMITED (JP) | 2006-12-05 | — | — | US | disclosed |
| US-5908858-A | OSTEOPOROSIS; LEUKOTRIENE INHIBITOR | SANKYO COMPANY, LIMITED (JP) | 1999-06-01 | — | — | US | disclosed |
| EP-0799823-A1 | 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1997-10-08 | — | — | EP | disclosed |