SCHEMBL5313367

SCHEMBL5313367

COC(=O)C(CC(=O)c1ccc(SC)cc1)C(C)=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HAO1 Q9UJM8 1/20 0.46
KMT2A Q03164 3/20 0.45
PLK1 P53350 1/20 0.42
TAS1R3 Q7RTX0 2/20 0.41
TAS1R1 Q7RTX1 2/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
MAPT P10636 5/20 0.38
ALDH1A1 P00352 4/20 0.38
LMNA P02545 2/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
HTT P42858 3/20 0.38
TSHR P16473 2/20 0.38
MMP2 P08253 1/20 0.38
MMP9 P14780 1/20 0.38
MMP8 P22894 1/20 0.38
GAA P10253 1/20 0.38
ALOX15 P16050 1/20 0.38
MEN1 O00255 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
KDM4E B2RXH2 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8535189 0.81 KMT2A (0.68) KMT2AL3MBTL1MAPTALDH1A1LMNA
SCHEMBL5315001 0.78 GSR (0.46) KMT2AL3MBTL1MMP2MMP9MMP8
SCHEMBL27481214 0.77 KMT2A (0.43) KMT2AL3MBTL1MAPTALDH1A1HTT
SCHEMBL5310617 0.77 HAO1 (0.43) HAO1KMT2APLK1TAS1R3TAS1R1
SCHEMBL19659999 0.74 L3MBTL1 (0.60) KMT2AL3MBTL1MAPTALDH1A1LMNA
SCHEMBL10848459 0.74 HAO1 (0.51) HAO1KMT2APLK1TAS1R3TAS1R1
SCHEMBL22281608 0.73 L3MBTL1 (0.64) KMT2AL3MBTL1ALDH1A1LMNASMN1; SMN2
SCHEMBL22281426 0.73 GSK3B (0.61) KMT2AL3MBTL1MAPTALDH1A1LMNA
SCHEMBL17290731 0.73 PLK1 (0.53) HAO1KMT2APLK1TAS1R3TAS1R1
SCHEMBL5768900 0.73 HAO1 (0.58) HAO1KMT2APLK1TAS1R3TAS1R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3004053-B1 A PROCESS FOR PREPARATION OF PYRROLES HAVING HYPOLIPIDEMIC HYPOCHOLESTEREMIC ACTIVITIES CADILA HEALTHCARE LTD (IN) 2021-03-24 EP disclosed
EP-3004053-B1 A PROCESS FOR PREPARATION OF PYRROLES HAVING HYPOLIPIDEMIC HYPOCHOLESTEREMIC ACTIVITIES CADILA HEALTHCARE LTD (IN) 2021-03-24 EP disclosed
US-10435363-B2 Process for preparation of pyrroles having hypolipidemic hypocholesteremic activities CADILA HEALTHCARE LIMITED (IN) 2019-10-08 US disclosed
US-10435363-B2 Process for preparation of pyrroles having hypolipidemic hypocholesteremic activities CADILA HEALTHCARE LIMITED (IN) 2019-10-08 US disclosed
US-10112898-B2 Process for the preparation of saroglitazar pharmaceutical salts CADILA HEALTHCARE LIMITED (IN) 2018-10-30 US disclosed
US-20170144968-A1 PROCESS FOR PREPARATION OF PYRROLES HAVING HYPOLIPIDEMIC HYPOCHOLESTEREMIC ACTIVITIES ZYDUS LIFESCIENCES LIMITED (IN) 2017-05-25 US disclosed
US-20170144968-A1 PROCESS FOR PREPARATION OF PYRROLES HAVING HYPOLIPIDEMIC HYPOCHOLESTEREMIC ACTIVITIES ZYDUS LIFESCIENCES LIMITED (IN) 2017-05-25 US disclosed
US-20170144968-A1 PROCESS FOR PREPARATION OF PYRROLES HAVING HYPOLIPIDEMIC HYPOCHOLESTEREMIC ACTIVITIES ZYDUS LIFESCIENCES LIMITED (IN) 2017-05-25 US disclosed
US-20160194280-A1 IMPROVED PROCESS FOR THE PREPARATION OF PYRROLE DERIVATIVES CADILA HEALTHCARE LIMITED (IN) 2016-07-07 US disclosed
US-20160194280-A1 IMPROVED PROCESS FOR THE PREPARATION OF PYRROLE DERIVATIVES CADILA HEALTHCARE LIMITED (IN) 2016-07-07 US disclosed
US-20160107989-A1 A PROCESS FOR PREPARATION OF PYRROLES HAVING HYPOLIPIDEMIC HYPOCHOLESTEREMIC ACTIVITIES CADILA HEALTHCARE LIMITED (IN) 2016-04-21 US disclosed
US-20160107989-A1 A PROCESS FOR PREPARATION OF PYRROLES HAVING HYPOLIPIDEMIC HYPOCHOLESTEREMIC ACTIVITIES CADILA HEALTHCARE LIMITED (IN) 2016-04-21 US disclosed
EP-3004053-A2 A PROCESS FOR PREPARATION OF PYRROLES HAVING HYPOLIPIDEMIC HYPOCHOLESTEREMIC ACTIVITIES Cadila Healthcare Limited (IN) 2016-04-13 EP disclosed
WO-2015033357-A2 AN IMPROVED PROCESS FOR THE PREPARATION OF PYRROLE DERIVATIVES CADILA HEALTHCARE LIMITED (IN) 2015-03-12 WO disclosed
WO-2015033357-A2 AN IMPROVED PROCESS FOR THE PREPARATION OF PYRROLE DERIVATIVES CADILA HEALTHCARE LIMITED (IN) 2015-03-12 WO disclosed
WO-2014195967-A2 A PROCESS FOR PREPARATION OF PYRROLES HAVING HYPOLIPIDEMIC HYPOCHOLESTEREMIC ACTIVITIES CADILA HEALTHCARE LIMITED (IN) 2014-12-11 WO disclosed
EP-0799823-B1 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses DAIICHI SANKYO CO LTD (JP) 2007-10-31 EP disclosed
US-RE39420-E1 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses SANKYO COMPANY, LIMITED (JP) 2006-12-05 US disclosed
US-5908858-A OSTEOPOROSIS; LEUKOTRIENE INHIBITOR SANKYO COMPANY, LIMITED (JP) 1999-06-01 US disclosed
EP-0799823-A1 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses SANKYO COMPANY LIMITED (JP) 1997-10-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160194280-A1 IMPROVED PROCESS FOR THE PREPARATION OF PYRROLE DERIVATIVES HPD, HMGCR, CYP51A1 HAO1 799/4885KMT2A 965/4885PLK1 1849/4885
US-20160107989-A1 A PROCESS FOR PREPARATION OF PYRROLES HAVING HYPOLIPIDEMIC HYPOCHOLESTEREMIC ACTIVITIES CYP51A1, DHCR7, LIPA HAO1 1178/4885KMT2A 2536/4885PLK1 1212/4885
US-20170144968-A1 PROCESS FOR PREPARATION OF PYRROLES HAVING HYPOLIPIDEMIC HYPOCHOLESTEREMIC ACTIVITIES CYP51A1, LIPA, DHCR7 HAO1 1312/4885KMT2A 2414/4885PLK1 1269/4885
US-10435363-B2 Process for preparation of pyrroles having hypolipidemic hypocholesteremic activities CYP51A1, LIPA, DHCR7 HAO1 1312/4885KMT2A 2414/4885PLK1 1269/4885
US-10112898-B2 Process for the preparation of saroglitazar pharmaceutical salts DPP4, CYP51A1, TPP1 HAO1 855/4885KMT2A 1079/4885PLK1 2727/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.