Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 6/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 3/20 | 0.40 |
| ▸ | UBE2M | P61081 | 1/20 | 0.38 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.38 |
| ▸ | TACR2 | P21452 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | IL1B | P01584 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | PDE8B | O95263 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5317186 | 1.00 | HTR4 (0.42) | HTR4CYP2D6CYP3A4NAMPTUBE2M | |
| SCHEMBL5314921 | 0.91 | HTR4 (0.48) | HTR4CYP2D6CYP3A4TACR2THRB | |
| SCHEMBL3707639 | 0.82 | CYP2D6 (0.46) | CYP2D6NAMPT | |
| SCHEMBL9956855 | 0.79 | CYP2D6 (0.53) | CYP2D6NAMPTPDE8B | |
| SCHEMBL16039173 | 0.75 | CYP2D6 (0.44) | CYP2D6NAMPT | |
| SCHEMBL5315253 | 0.73 | NCF1 (0.41) | HTR4NAMPTUBE2MDCUN1D1 | |
| SCHEMBL2053924 | 0.73 | EPHX1 (0.56) | CYP2D6 | |
| SCHEMBL5316533 | 0.73 | NCF1 (0.41) | HTR4NAMPTUBE2MDCUN1D1 | |
| SCHEMBL12671 | 0.71 | CHRM5 (0.52) | HTR4NAMPT | |
| SCHEMBL3164794 | 0.71 | HTR4 (0.53) | HTR4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007068739-A1 | 4-AMINO-BENZAMIDE DERIVATIVES AS 5-HT4 RECEPTOR AGONISTS FOR THE TREATMENT OF GASTROINTESTINAL, NEUROLOGICAL AND CARDIOVASCULAR DISORDERS | GLAXO GROUP LIMITED (GB) | 2007-06-21 | — | — | WO | disclosed |