Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | DUSP10 | Q9Y6W6 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5914308 | 0.82 | AURKA (0.39) | IKBKBAURKAHSP90AA1PRKACAADORA2A | |
| SCHEMBL27997668 | 0.78 | AURKA (0.50) | IKBKBAURKAHSP90AA1PRKACAADORA2A | |
| SCHEMBL5914113 | 0.74 | MEN1 (0.39) | IKBKBAURKAHSP90AA1PRKACAADORA2A | |
| SCHEMBL28886710 | 0.64 | AURKA (0.55) | AURKAHSP90AA1PRKACAADORA2AKMT2A | |
| SCHEMBL4490141 | 0.64 | MEN1 (0.49) | ALDH1A1KMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL14507076 | 0.64 | IKBKB (0.46) | IKBKBAURKAHSP90AA1PRKACAADORA2A | |
| SCHEMBL5914297 | 0.64 | GABRA1 (0.38) | ADORA2A | |
| SCHEMBL4447801 | 0.63 | BPTF (0.54) | IKBKBAURKAHSP90AA1PRKACAADORA2A | |
| SCHEMBL5914145 | 0.62 | IKBKB (0.37) | IKBKBAURKAHSP90AA1PRKACAADORA2A | |
| SCHEMBL14507077 | 0.62 | HSP90AA1 (0.41) | IKBKBAURKAHSP90AA1PRKACAADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794135-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006037117-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-04-06 | — | — | WO | disclosed |