Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | PRKACA | P17612 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | DUSP10 | Q9Y6W6 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ASIC3 | Q9UHC3 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4490141 | 0.83 | MEN1 (0.49) | KMT2AMEN1RAB9AMAPTKDM4E | |
| SCHEMBL5914308 | 0.83 | AURKA (0.39) | AURKAHSP90AA1PRKACAADORA2AKMT2A | |
| SCHEMBL6070210 | 0.80 | TGFBR1 (0.56) | AURKAPRKACAPRKCDFGFR1RPS6KA3 | |
| SCHEMBL5726072 | 0.80 | TGFBR1 (0.48) | AURKAPRKACAKDM4EPRKCDMAPK8 | |
| SCHEMBL5914113 | 0.80 | MEN1 (0.39) | AURKAHSP90AA1PRKACAADORA2AKMT2A | |
| SCHEMBL5315985 | 0.78 | IKBKB (0.36) | AURKAHSP90AA1PRKACAADORA2AKMT2A | |
| SCHEMBL5780175 | 0.78 | ADORA2A (0.36) | ADORA2AMAPTKDM4EL3MBTL1NPSR1 | |
| SCHEMBL5777962 | 0.78 | ALDH1A1 (0.52) | KMT2AMEN1MAPTKDM4EPOLB | |
| SCHEMBL5727412 | 0.77 | MAPK1 (0.51) | AURKAHSP90AA1PRKACAADORA2AKMT2A | |
| SCHEMBL27618478 | 0.76 | MAPK8 (0.52) | AURKAMAPTMAPK8CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104271576-A | Pyridopyrimidinone inhibitors of kinases | ABBVIE INC | 2015-01-07 | — | — | CN | disclosed |