Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5315904 | 1.00 | ALDH1A1 (0.35) | ALDH1A1KDM4EMEN1NPC1MITF | |
| SCHEMBL4970440 | 0.85 | CYP2C19 (0.36) | ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL5318676 | 0.84 | ALDH1A1 (0.37) | ALDH1A1KDM4ESMN1; SMN2TSHRMAPT | |
| SCHEMBL8982330 | 0.77 | ADH1B (0.39) | ALDH1A1TSHRMAPT | |
| SCHEMBL5593518 | 0.73 | REN (0.41) | ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL16055688 | 0.73 | ALDH1A1 (0.37) | ALDH1A1MEN1KMT2A | |
| SCHEMBL28324607 | 0.73 | ALDH1A1 (0.37) | ALDH1A1MEN1KMT2A | |
| SCHEMBL5850034 | 0.73 | ALDH1A1 (0.37) | ALDH1A1MAPT | |
| SCHEMBL28333138 | 0.73 | ALDH1A1 (0.37) | ALDH1A1MEN1KMT2A | |
| SCHEMBL4972273 | 0.72 | CYP2C19 (0.36) | ALDH1A1MEN1KMT2ATSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007117557-A2 | DIAMINOPROPANOL RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |