Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 9/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5593512 | 0.80 | MEN1 (0.33) | RENNAAAEPHX1MEN1ALDH1A1 | |
| SCHEMBL4970440 | 0.77 | CYP2C19 (0.36) | EPHX1MEN1ALDH1A1KMT2ATSHR | |
| SCHEMBL5318676 | 0.73 | ALDH1A1 (0.37) | ALDH1A1TSHR | |
| SCHEMBL5316108 | 0.73 | ALDH1A1 (0.35) | MEN1ALDH1A1KMT2ATSHR | |
| SCHEMBL5315904 | 0.73 | ALDH1A1 (0.35) | MEN1ALDH1A1KMT2ATSHR | |
| SCHEMBL3564204 | 0.71 | REN (0.68) | RENNAAAEPHX1ALDH1A1KMT2A | |
| SCHEMBL3564248 | 0.71 | REN (0.49) | RENMETAP2 | |
| SCHEMBL3564246 | 0.71 | REN (0.49) | RENMETAP2 | |
| SCHEMBL5593651 | 0.69 | REN (0.50) | RENNAAAEPHX1ALDH1A1KMT2A | |
| SCHEMBL3261774 | 0.69 | NAAA (0.46) | NAAAEPHX1MEN1KMT2AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007117560-A2 | PIPERIDINE AND MORPHOLINE RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |