Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.57 |
| ▸ | PPP1R15A | O75807 | 1/20 | 0.57 |
| ▸ | MELK | Q14680 | 1/20 | 0.57 |
| ▸ | PPP1R15B | Q5SWA1 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3301728 | 0.76 | PPP1R15A (0.42) | L3MBTL1PPP1R15AMELKPPP1R15BNPSR1 | |
| SCHEMBL31241325 | 0.76 | L3MBTL1 (0.50) | L3MBTL1PPP1R15AMELKPPP1R15BNPSR1 | |
| SCHEMBL11405071 | 0.76 | L3MBTL1 (0.50) | L3MBTL1PPP1R15AMELKPPP1R15BNPSR1 | |
| SCHEMBL11405068 | 0.76 | L3MBTL1 (0.50) | L3MBTL1PPP1R15AMELKPPP1R15BNPSR1 | |
| SCHEMBL11309438 | 0.75 | GRIN2D (0.67) | L3MBTL1PPP1R15AMELKPPP1R15BNPSR1 | |
| SCHEMBL11309449 | 0.75 | GRIN2D (0.67) | L3MBTL1PPP1R15AMELKPPP1R15BNPSR1 | |
| SCHEMBL1058816 | 0.75 | NFE2L2 (0.50) | L3MBTL1PPP1R15AMELKPPP1R15BNPSR1 | |
| SCHEMBL1130162 | 0.74 | LMNA (1.00) | L3MBTL1LMNAKMT2AALDH1A1CHRM5 | |
| SCHEMBL396304 | 0.74 | LMNA (1.00) | L3MBTL1LMNAKMT2AALDH1A1CHRM5 | |
| SCHEMBL1119267 | 0.74 | LMNA (1.00) | L3MBTL1LMNAKMT2AALDH1A1CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007035823-A2 | PARTIAL MGLUR5 ANTAGONISTS AND METHODS OF USE THEREOF | MOLECULAR NEUROIMAGING, LLC (US) | 2007-03-29 | — | — | WO | disclosed |