Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 1/20 | 0.48 |
| ▸ | METAP2 | P50579 | 1/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.48 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | PRKX | P51817 | 1/20 | 0.45 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.44 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.44 |
| ▸ | FLT1 | P17948 | 2/20 | 0.44 |
| ▸ | FLT4 | P35916 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5336680 | 0.88 | IMPDH2 (0.59) | IMPDH2ROCK1CLK4FLT1FLT4 | |
| SCHEMBL5335613 | 0.88 | CDC7 (0.58) | IMPDH2MKNK1ROCK2ROCK1MAPKAPK2 | |
| SCHEMBL5333863 | 0.88 | VCP (0.58) | IMPDH2MKNK1ROCK2ROCK1MAPKAPK2 | |
| SCHEMBL5343891 | 0.88 | VCP (0.58) | NOS1IMPDH2MKNK1ROCK2PRKACA | |
| SCHEMBL5333205 | 0.88 | IMPDH2 (0.53) | IMPDH2MKNK1ROCK2ROCK1MAPKAPK2 | |
| SCHEMBL5336433 | 0.88 | MKNK1 (0.51) | IMPDH2MEN1KMT2AMKNK1ROCK2 | |
| SCHEMBL14465941 | 0.88 | IMPDH2 (0.61) | IMPDH2ROCK1CLK4FLT1FLT4 | |
| SCHEMBL5317043 | 0.85 | IMPDH2 (0.45) | IMPDH2MKNK1ROCK2ROCK1MAPKAPK2 | |
| SCHEMBL5374741 | 0.85 | FLT1 (0.54) | IMPDH2MEN1KMT2AMKNK1ROCK2 | |
| SCHEMBL14466977 | 0.85 | TRPV1 (0.61) | IMPDH2MEN1KMT2AMKNK1MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |