Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 7/20 | 0.58 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.52 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5339924 | 0.88 | MKNK1 (0.57) | VCPTNIKPIK3CAIMPDH2ALOX5 | |
| SCHEMBL5343891 | 0.88 | VCP (0.58) | VCPTNIKIMPDH2MKNK1MAPKAPK2 | |
| SCHEMBL5316809 | 0.88 | NOS1 (0.48) | VCPTNIKIMPDH2MKNK1MAPKAPK2 | |
| SCHEMBL5336680 | 0.88 | IMPDH2 (0.59) | VCPPIK3CAIMPDH2FLT1KDR | |
| SCHEMBL5333205 | 0.88 | IMPDH2 (0.53) | VCPTNIKIMPDH2ALOX5MKNK1 | |
| SCHEMBL5335613 | 0.88 | CDC7 (0.58) | VCPTNIKIMPDH2ALOX5MKNK1 | |
| SCHEMBL5336433 | 0.88 | MKNK1 (0.51) | VCPTNIKIMPDH2MKNK1MAPKAPK2 | |
| SCHEMBL14465941 | 0.88 | IMPDH2 (0.61) | VCPPIK3CAIMPDH2FLT1KDR | |
| SCHEMBL5374741 | 0.87 | FLT1 (0.54) | VCPTNIKIMPDH2MKNK1MAPKAPK2 | |
| SCHEMBL5342613 | 0.86 | VCP (0.50) | VCPTNIKIMPDH2MAPKAPK2FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |