Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | SIRT7 | Q9NRC8 | 1/20 | 0.51 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5333205 | 0.88 | IMPDH2 (0.53) | MKNK1EGFRMAPKAPK2ROCK2ROCK1 | |
| SCHEMBL5333863 | 0.88 | VCP (0.58) | MKNK1MAPKAPK2ROCK2ROCK1IMPDH2 | |
| SCHEMBL5335613 | 0.88 | CDC7 (0.58) | MKNK1MAPKAPK2ROCK2RAB9AROCK1 | |
| SCHEMBL5336680 | 0.88 | IMPDH2 (0.59) | EGFRROCK1IMPDH2FLT1FLT4 | |
| SCHEMBL5316809 | 0.88 | NOS1 (0.48) | MKNK1EGFRSIRT7MAPKAPK2ROCK2 | |
| SCHEMBL5343891 | 0.88 | VCP (0.58) | MKNK1SIRT7MAPKAPK2ROCK2ROCK1 | |
| SCHEMBL14465941 | 0.88 | IMPDH2 (0.61) | EGFRROCK1IMPDH2FLT1FLT4 | |
| SCHEMBL14466075 | 0.85 | ROCK2 (0.62) | MKNK1EGFRSIRT7MAPKAPK2ROCK2 | |
| SCHEMBL5317043 | 0.85 | IMPDH2 (0.45) | MKNK1SIRT7MAPKAPK2ROCK2ROCK1 | |
| SCHEMBL5336169 | 0.85 | MEN1 (0.51) | MKNK1MAPKAPK2ROCK2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |