SCHEMBL5316901

SCHEMBL5316901

FC(F)(F)c1cnc([S])c(Cl)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.58
PLAU P00749 1/20 0.54
POLB P06746 2/20 0.50
KDM4E B2RXH2 2/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
HTT P42858 4/20 0.47
GAA P10253 2/20 0.47
L3MBTL1 Q9Y468 2/20 0.46
TDP1 Q9NUW8 1/20 0.46
MAPT P10636 3/20 0.45
LMNA P02545 1/20 0.45
GLA P06280 1/20 0.45
HPGD P15428 1/20 0.45
NPC1 O15118 2/20 0.44
RAB9A P51151 2/20 0.44
NPSR1 Q6W5P4 2/20 0.44
MEN1 O00255 1/20 0.44
OPRK1 P41145 1/20 0.44
KMT2A Q03164 1/20 0.44
MAPK1 P28482 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30353712 1.00 ALDH1A1 (0.58) ALDH1A1PLAUPOLBKDM4ESMN1; SMN2
SCHEMBL120994 0.78 ALDH1A1 (0.56) ALDH1A1PLAUPOLBKDM4ESMN1; SMN2
SCHEMBL29414916 0.78 ALDH1A1 (0.56) ALDH1A1PLAUPOLBKDM4ESMN1; SMN2
SCHEMBL29721809 0.77 ALDH1A1 (0.55) ALDH1A1PLAUPOLBKDM4ESMN1; SMN2
SCHEMBL30285317 0.77 ALDH1A1 (0.55) ALDH1A1PLAUPOLBKDM4ESMN1; SMN2
SCHEMBL805963 0.77 ALDH1A1 (0.55) ALDH1A1PLAUPOLBKDM4ESMN1; SMN2
SCHEMBL1971207 0.75 ALDH1A1 (0.58) ALDH1A1PLAUPOLBKDM4ESMN1; SMN2
SCHEMBL166766 0.75 ALDH1A1 (0.53) ALDH1A1PLAUPOLBKDM4ESMN1; SMN2
SCHEMBL119730 0.75 ALDH1A1 (0.59) ALDH1A1PLAUPOLBKDM4ESMN1; SMN2
SCHEMBL3464720 0.75 ALDH1A1 (0.53) ALDH1A1PLAUPOLBKDM4ESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108368064-B 1,2, 3-triazole derivative and insecticide and acaricide comprising the same as active ingredient 北兴化学工业株式会社 2022-04-26 CN disclosed
US-11046659-B2 1,2,3-triazole derivative and insecticide and acaricide containing said derivative as active ingredient HOKKO CHEMICAL INDUSTRY CO., LTD. (JP) 2021-06-29 US disclosed
US-20190322630-A1 1,2,3-TRIAZOLE DERIVATIVE AND INSECTICIDE AND ACARICIDE CONTAINING SAID DERIVATIVE AS ACTIVE INGREDIENT HOKKO CHEMICAL INDUSTRY CO., LTD. (JP) 2019-10-24 US disclosed
US-10377737-B2 1,2,3-triazole derivative and insecticide and acaricide containing said derivative as active ingredient HOKKO CHEMICAL INDUSTRY CO., LTD. (JP) 2019-08-13 US disclosed
US-20180290986-A1 1,2,3-TRIAZOLE DERIVATIVE AND INSECTICIDE AND ACARICIDE CONTAINING SAID DERIVATIVE AS ACTIVE INGREDIENT HOKKO CHEMICAL INDUSTRY CO., LTD. (JP) 2018-10-11 US disclosed
EP-3385254-A1 1,2,3-TRIAZOLE DERIVATIVE AND INSECTICIDE/ACARICIDE HAVING SAID DERIVATIVE AS ACTIVE INGREDIENT Hokko Chemical Industry Co., Ltd. (JP) 2018-10-10 EP disclosed
US-9963451-B2 Fused ring pyrimidine compound and pest control agent containing the same MITSUI CHEMICALS AGRO, INC. (JP) 2018-05-08 US disclosed
US-20150368249-A1 FUSED RING PYRIMIDINE COMPOUND AND PEST CONTROL AGENT CONTAINING THE SAME MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) 2015-12-24 US disclosed
WO-2007066496-A1 BENZOYLUREA COMPOUND AND USE THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-06-14 WO disclosed
US-6762197-B2 FUNGICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2004-07-13 US disclosed
EP-1238975-A1 DIFLUOROMETHYLTRIAZOLONE COMPOUNDS, USE OF THE SAME AND INTERMEDIATES FOR THE PRODUCTION THEREOF Sumitomo Chemical Company, Limited (JP) 2002-09-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180290986-A1 1,2,3-TRIAZOLE DERIVATIVE AND INSECTICIDE AND ACARICIDE CONTAINING SAID DERIVATIVE AS ACTIVE INGREDIENT AADAC, CYP51A1, NAT1 ALDH1A1 89/4885PLAU 4822/4885POLB 4724/4885
US-10377737-B2 1,2,3-triazole derivative and insecticide and acaricide containing said derivative as active ingredient AADAC, CYP51A1, NAT1 ALDH1A1 89/4885PLAU 4822/4885POLB 4724/4885
US-20150368249-A1 FUSED RING PYRIMIDINE COMPOUND AND PEST CONTROL AGENT CONTAINING THE SAME CBR3, HRH2, HRH4 ALDH1A1 3675/4885PLAU 4611/4885POLB 1030/4885
US-11046659-B2 1,2,3-triazole derivative and insecticide and acaricide containing said derivative as active ingredient AADAC, CYP51A1, NAT1 ALDH1A1 89/4885PLAU 4822/4885POLB 4724/4885
US-20190322630-A1 1,2,3-TRIAZOLE DERIVATIVE AND INSECTICIDE AND ACARICIDE CONTAINING SAID DERIVATIVE AS ACTIVE INGREDIENT AADAC, CYP51A1, NAT1 ALDH1A1 89/4885PLAU 4822/4885POLB 4724/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.