Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 5/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | JAK1 | P23458 | 2/20 | 0.44 |
| ▸ | TYK2 | P29597 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.43 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.43 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5318291 | 0.90 | L3MBTL1 (0.54) | MAPK8L3MBTL1HDAC6PTGER4HPGD | |
| SCHEMBL5315400 | 0.81 | FLT3 (0.48) | — | |
| SCHEMBL5320017 | 0.77 | HDAC6 (0.50) | L3MBTL1HDAC6PTGER4RAF1BRAF | |
| SCHEMBL6320502 | 0.76 | HDAC6 (0.53) | L3MBTL1HDAC6PTGER4HPGDHCAR3 | |
| SCHEMBL1970364 | 0.73 | HDAC6 (0.57) | L3MBTL1HDAC6PTGER4HPGDHCAR3 | |
| SCHEMBL5316684 | 0.72 | HCAR3 (0.50) | HDAC6HPGDHCAR3EHMT2EHMT1 | |
| SCHEMBL558517 | 0.72 | CSNK2A1 (0.58) | MAPK8CSNK2A1CSNK2A2CSNK2BHCAR3 | |
| SCHEMBL558518 | 0.72 | CSNK2A1 (0.58) | MAPK8CSNK2A1CSNK2A2CSNK2BHCAR3 | |
| SCHEMBL1144927 | 0.71 | HCAR3 (0.55) | L3MBTL1HDAC6PTGER4HPGDHCAR3 | |
| SCHEMBL554569 | 0.71 | HSD17B10 (0.64) | L3MBTL1HCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069053-A1 | BENZIMIDAZOLE ANTAGONISTS OF THE H-3 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-06-21 | — | — | WO | disclosed |