Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | RAF1 | P04049 | 1/20 | 0.53 |
| ▸ | BRAF | P15056 | 1/20 | 0.53 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.48 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.48 |
| ▸ | HCAR3 | P49019 | 6/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5317040 | 0.90 | MAPK8 (0.59) | L3MBTL1RAF1BRAFCSNK2A2CSNK2B | |
| SCHEMBL5320017 | 0.79 | HDAC6 (0.50) | L3MBTL1RAF1BRAFHCAR3HSD17B10 | |
| SCHEMBL6320502 | 0.78 | HDAC6 (0.53) | L3MBTL1HCAR3HSD17B10HDAC6PTGER4 | |
| SCHEMBL14263330 | 0.77 | KDM4E (0.51) | RAF1BRAFHSD17B10GAAKCNH2 | |
| SCHEMBL5318329 | 0.76 | ITK (0.51) | RAF1BRAFHDAC6KCNH2 | |
| SCHEMBL15019951 | 0.76 | L3MBTL1 (0.56) | L3MBTL1HCAR3HSD17B10GAAHDAC6 | |
| SCHEMBL4258690 | 0.76 | HDAC6 (0.53) | L3MBTL1HCAR3HSD17B10GAAHDAC6 | |
| SCHEMBL1970364 | 0.75 | HDAC6 (0.57) | L3MBTL1HCAR3HSD17B10HDAC6PTGER4 | |
| SCHEMBL4978261 | 0.75 | PKM (0.56) | L3MBTL1RAF1BRAFGAA | |
| SCHEMBL25243334 | 0.75 | CSNK2A1 (0.52) | L3MBTL1CSNK2A2CSNK2BCSNK2A1HCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069053-A1 | BENZIMIDAZOLE ANTAGONISTS OF THE H-3 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-06-21 | — | — | WO | disclosed |