Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 7/20 | 0.36 |
| ▸ | HTR1A | P08908 | 4/20 | 0.36 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5317191 | 0.91 | POLB (0.44) | KCNH2POLBCYP2C19LMNASMN1; SMN2 | |
| SCHEMBL5319733 | 0.90 | POLB (0.48) | KCNH2POLBTSHRKCNJ1HTT | |
| SCHEMBL5331515 | 0.88 | LMNA (0.50) | KCNH2POLBLMNASMN1; SMN2TSHR | |
| SCHEMBL5317453 | 0.87 | KMT2A (0.48) | KCNH2POLBSMN1; SMN2KCNJ1DRD2 | |
| SCHEMBL5317594 | 0.86 | HTR1A (0.40) | KCNH2POLBTSHRHTTDRD2 | |
| SCHEMBL5316699 | 0.84 | CA1 (0.44) | KCNH2POLBCHRNA7KCNJ1ALDH1A1 | |
| SCHEMBL5316522 | 0.84 | POLB (0.43) | KCNH2POLBSMN1; SMN2TSHRKCNJ1 | |
| SCHEMBL5314874 | 0.83 | POLB (0.54) | POLBLMNASMN1; SMN2TSHRHTT | |
| SCHEMBL5315892 | 0.83 | POLB (0.45) | KCNH2POLBCHRNA7KCNJ1DRD2 | |
| SCHEMBL5343106 | 0.82 | KCNH2 (0.48) | KCNH2POLBLMNAKCNJ1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | disclosed |