Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | KIT | P10721 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 3/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5317819 | 1.00 | ENPP2 (0.41) | ENPP2PTGS2KITLMNAMAPK8 | |
| SCHEMBL5318927 | 0.91 | LMNA (0.44) | ENPP2PTGS2LMNAPPARG | |
| SCHEMBL5318933 | 0.91 | LMNA (0.44) | ENPP2PTGS2LMNAPPARG | |
| SCHEMBL5318755 | 0.91 | RXRA (0.40) | ENPP2PTGS2PTGDR2NR1H2NR1H3 | |
| SCHEMBL5318756 | 0.91 | RXRA (0.40) | ENPP2PTGS2PTGDR2NR1H2NR1H3 | |
| SCHEMBL5319156 | 0.91 | ENPP2 (0.48) | ENPP2LMNAGRM2PTGDR2NR1H2 | |
| SCHEMBL5319158 | 0.91 | ENPP2 (0.48) | ENPP2LMNAGRM2PTGDR2NR1H2 | |
| SCHEMBL5318848 | 0.90 | PTGS2 (0.39) | ENPP2PTGS2LMNAMAPK8PPARG | |
| SCHEMBL5318851 | 0.90 | PTGS2 (0.39) | ENPP2PTGS2LMNAMAPK8PPARG | |
| SCHEMBL5317790 | 0.90 | ENPP2 (0.45) | ENPP2KITGRM2PTGDR2NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786424-A2 | LONIDAMINE ANALOGUES AND THEIR USE IN MALE CONTRACEPTION AND CANCER TREATMENT | The University of Kansas (US) | 2007-05-23 | — | — | EP | claimed |
| WO-2006023704-A2 | LONIDAMINE ANALOGUES AND THEIR USE IN MALE CONTRACEPTION AND CANCER TREATMENT | UNIVERSITY OF KANSAS (US) | 2006-03-02 | — | — | WO | claimed |