Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.33 |
| ▸ | JMJD1C | Q15652 | 1/20 | 0.33 |
| ▸ | KDM3B | Q7LBC6 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5262710 | 0.89 | EPHB4 (0.42) | CAMK2DCNR2MAP4K4MAPKAPK2KMO | |
| SCHEMBL5913998 | 0.89 | EPHB4 (0.42) | CAMK2DCNR2MAP4K4MAPKAPK2KMO | |
| SCHEMBL5266372 | 0.80 | EPHB4 (0.44) | EPHB4DYRK1BKDRMAPK14 | |
| SCHEMBL5317588 | 0.79 | CAMK2D (0.38) | CAMK2DIDH1CNR2MAP4K4MAPKAPK2 | |
| SCHEMBL5315516 | 0.75 | MAPK14 (0.38) | IDH1KDRMAPK14MAPK1 | |
| SCHEMBL5914384 | 0.71 | CFD (0.41) | CAMK2DIDH1EPHB4DYRK1BKDR | |
| SCHEMBL5914162 | 0.70 | HPGDS (0.40) | IDH1KDRMAPK14MAPK1 | |
| SCHEMBL5914169 | 0.70 | HPGDS (0.40) | IDH1KDRMAPK14MAPK1 | |
| SCHEMBL5317833 | 0.69 | KDR (0.40) | EPHB4KDRMAPK14 | |
| SCHEMBL5314939 | 0.69 | KDR (0.40) | EPHB4KDRMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794135-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006037117-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-04-06 | — | — | WO | disclosed |