Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 11/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.41 |
| ▸ | PTPRC | P08575 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 3/20 | 0.40 |
| ▸ | THRB | P10828 | 3/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | EPM2A | O95278 | 1/20 | 0.39 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.39 |
| ▸ | PGK1 | P00558 | 1/20 | 0.36 |
| ▸ | PGK2 | P07205 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5389043 | 0.91 | IDO1 (0.42) | IDO1PTPN1PTPN2PTPRCHDAC1 | |
| SCHEMBL5319160 | 0.80 | PTPN1 (0.46) | PTPN1PTPN2PTPRCHDAC1HDAC2 | |
| SCHEMBL5320495 | 0.79 | CACNB4 (0.45) | PTPN1PTPN2PTPRCHDAC1HDAC8 | |
| SCHEMBL5343124 | 0.77 | PTPN1 (0.47) | PTPN1PTPN2PTPRC | |
| SCHEMBL5337560 | 0.76 | HDAC6 (0.55) | PTPN1PTPN2PTPRCHDAC1HDAC2 | |
| SCHEMBL5320081 | 0.76 | PTPN2 (0.45) | PTPN1PTPN2PTPRCHDAC1HDAC2 | |
| SCHEMBL5342941 | 0.75 | PLA2G2A (0.51) | PTPN1PTPN2PTPRCHDAC1HDAC8 | |
| SCHEMBL5317466 | 0.75 | HDAC1 (0.45) | IDO1PTPN1PTPN2PTPRCHDAC1 | |
| SCHEMBL4894921 | 0.75 | PTPN1 (0.49) | PTPN1PTPN2PTPRCPGK1PGK2 | |
| SCHEMBL5320802 | 0.75 | HDAC1 (0.44) | PTPN1PTPN2PTPRCHDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007081755-A2 | INDOLE-BENZIMIDAZOLE AND INDAZOLE INHIBITORS OF TYROSINE PHOSPHATASES | METABASIS THERAPEUTICS, INC. (US) | 2007-07-19 | — | — | WO | claimed |
| WO-2007081755-A2 | INDOLE-BENZIMIDAZOLE AND INDAZOLE INHIBITORS OF TYROSINE PHOSPHATASES | METABASIS THERAPEUTICS, INC. (US) | 2007-07-19 | — | — | WO | disclosed |