Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 8/20 | 0.48 |
| ▸ | VCP | P55072 | 2/20 | 0.45 |
| ▸ | FLT1 | P17948 | 2/20 | 0.45 |
| ▸ | FLT4 | P35916 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | JAK1 | P23458 | 3/20 | 0.42 |
| ▸ | JAK3 | P52333 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5319664 | 0.84 | FLT1 (0.57) | IMPDH2VCPFLT1FLT4KDR | |
| SCHEMBL5316768 | 0.84 | FLT1 (0.54) | IMPDH2VCPFLT1FLT4KDR | |
| SCHEMBL5319120 | 0.83 | VCP (0.62) | IMPDH2VCPFLT1FLT4KDR | |
| SCHEMBL14466043 | 0.76 | IMPDH2 (0.53) | IMPDH2VCPFLT1FLT4KDR | |
| SCHEMBL5316815 | 0.76 | KDR (0.57) | IMPDH2VCPFLT1FLT4KDR | |
| SCHEMBL5319083 | 0.75 | GRIA1 (0.43) | IMPDH2FLT1FLT4KDRSMN1; SMN2 | |
| SCHEMBL5318423 | 0.74 | VCP (0.56) | IMPDH2VCPFLT1FLT4KDR | |
| SCHEMBL5321701 | 0.74 | ALOX5 (0.52) | IMPDH2VCPFLT1FLT4KDR | |
| SCHEMBL1736665 | 0.73 | JAK1 (0.52) | SMN1; SMN2JAK2JAK1JAK3MEN1 | |
| SCHEMBL14465953 | 0.72 | FLT1 (0.58) | IMPDH2VCPFLT1FLT4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |