SCHEMBL5318471

SCHEMBL5318471

O=C(ON1CCC(Oc2ccc(F)cc2F)CC1)C(F)(F)F

nearest known ligand 0.50

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR6 P46095 19/20 0.50
GPR119 Q8TDV5 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2253897 0.85 GPR119 (0.42) GPR6GPR119
SCHEMBL69824 0.79 SCD (0.55)
SCHEMBL69694 0.79 SCD (0.44)
SCHEMBL2776116 0.79 GPR119 (0.69) GPR119
SCHEMBL28101022 0.78 FPR2 (0.49) GPR6GPR119
SCHEMBL27805795 0.78 GPR119 (0.41) GPR6GPR119
SCHEMBL28072761 0.77 GPR6 (0.48) GPR6GPR119
Trifluoroacetic Acid SCHEMBL5318468 0.76 GPR6 (0.50) GPR6
SCHEMBL29555 0.76 GRIN1 (0.43) GPR6
SCHEMBL19262515 0.76 GPR6 (0.51) GPR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007082079-A2 PIPERIDINE AMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS THE SCRIPPS RESEARCH INSTITUTE (US) 2007-07-19 WO disclosed