SCHEMBL5318665

SCHEMBL5318665

CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(-n3ccnc3)cc2)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.62
CYP2D6 P10635 1/20 0.62
PSEN1 P49768 1/20 0.62
PSEN2 P49810 1/20 0.62
APH1B Q8WW43 1/20 0.62
NCSTN Q92542 1/20 0.62
APH1A Q96BI3 1/20 0.62
PSENEN Q9NZ42 1/20 0.62
ALDH1A1 P00352 9/20 0.58
HTT P42858 3/20 0.58
POLB P06746 2/20 0.58
SMN1; SMN2 Q16637 2/20 0.58
LMNA P02545 2/20 0.58
NPSR1 Q6W5P4 2/20 0.58
TDP1 Q9NUW8 2/20 0.58
MAPT P10636 6/20 0.57
MEN1 O00255 4/20 0.57
KMT2A Q03164 4/20 0.57
CYP1A2 P05177 1/20 0.57
CYP2C19 P33261 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7129864 0.83 CYP3A4 (0.66) CYP3A4CYP2D6PSEN1PSEN2APH1B
SCHEMBL270275 0.82 MAPT (0.58) CYP3A4CYP2D6ALDH1A1HTTSMN1; SMN2
SCHEMBL812679 0.80 ALDH1A1 (0.83) CYP3A4ALDH1A1HTTPOLBSMN1; SMN2
SCHEMBL12042479 0.79 ALDH1A1 (0.76) CYP3A4ALDH1A1HTTPOLBSMN1; SMN2
SCHEMBL8487067 0.77 MAPT (0.56) CYP3A4CYP2D6ALDH1A1HTTPOLB
SCHEMBL24254524 0.77 CYP3A4 (0.61) CYP3A4CYP2D6PSEN1PSEN2APH1B
SCHEMBL4880963 0.76 CYP3A4 (0.64) CYP3A4CYP2D6PSEN1PSEN2APH1B
SCHEMBL1040954 0.74 ALDH1A1 (0.73) CYP3A4ALDH1A1HTTPOLBSMN1; SMN2
SCHEMBL13433558 0.74 ALDH1A1 (0.73) CYP3A4ALDH1A1HTTPOLBSMN1; SMN2
SCHEMBL7364379 0.74 ALDH1A1 (0.68) CYP3A4ALDH1A1HTTPOLBSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022182982-A1 METHODS FOR TREATING C-KIT KINASE MEDIATED DISEASES AND DISORDERS USING A SELECTIVE C-KIT KINASE INHIBITOR THIRD HARMONIC BIO, INC. (US) 2022-09-01 WO claimed
US-20250295659-A1 METHODS FOR TREATING TRAUMATIC BRAIN INJURY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-09-25 US disclosed
US-12295955-B2 TTP phosphorylation for the identification of personalized medicines KING FAISAL SPECIALIST HOSPITAL & RESEARCH CENTRE (SA) 2025-05-13 US disclosed
EP-4529477-A1 POROUS EXPANDING BIOCOMPATIBLE SCAFFOLDS Danmarks Tekniske Universitet (DK) 2025-04-02 EP disclosed
EP-4529468-A1 FORMULATION OF API'S AND EXCIPIENT'S IN AN ICELL VIA HYDROPHOBIC ION PAIRING Danmarks Tekniske Universitet (DK) 2025-04-02 EP disclosed
US-20240390406-A1 PHOSPHORYLATED TRISTETRAPROLIN AS A BIOMARKER AND THERAPEUTIC TARGET FOR ANTIAGING DRUGS KING FAISAL SPECIALIST HOSPITAL & RESEARCH CENTRE (SA) 2024-11-28 US disclosed
EP-4467978-A1 PHOSPHORYLATED TRISTETRAPROLIN AS A BIOMARKER AND THERAPEUTIC TARGET FOR ANTI-AGING DRUGS King Faisal Specialist Hospital & Research Centre (SA) 2024-11-27 EP disclosed
US-11865176-B2 Compositions and methods of modulating anti-tumor immunity DANA-FARBER CANCER INSTITUTE, INC. (US) 2024-01-09 US disclosed
US-20230398146-A1 IMMUNE MODULATION OF MYELOID DERIVED SUPPRESSIVE CELL FUNCTION FOR CANCER TREATMENT SURGE Therapeutics, Inc. 2023-12-14 US disclosed
WO-2023227518-A1 POROUS EXPANDING BIOCOMPATIBLE SCAFFOLDS DANMARKS TEKNISKE UNIVERSITET (DK) 2023-11-30 WO disclosed
EP-4282435-A1 FORMULATIONS OF ACTIVE PHARMACEUTICAL INGREDIENTS AND EXCIPIENTS IN ICELLS VIA HYDROPHOBIC ION PAIRING Danmarks Tekniske Universitet (DK) 2023-11-29 EP disclosed
EP-4282448-A1 POROUS EXPANDING BIOCOMPATIBLE SCAFFOLDS Danmarks Tekniske Universitet (DK) 2023-11-29 EP disclosed
CN-116322702-A Immunomodulation of myeloid-derived suppressor cell function for cancer treatment 萨吉治疗公司 2023-06-23 CN disclosed
EP-4196122-A1 IMMUNE MODULATION OF MYELOID DERIVED SUPPRESSIVE CELL FUNCTION FOR CANCER TREATMENT Surge Therapeutics, Inc. (US) 2023-06-21 EP disclosed
US-11648251-B2 TTP phosphorylation as a biomarker in targeted therapy KING FAISAL SPECIALIST HOSPITAL & RESEARCH CENTRE (SA) 2023-05-16 US disclosed
US-20220339285-A1 DISSACHARIDE FORMULATIONS FOR CONTROLLED DRUG RELEASE TECHNICAL UNIVERSITY OF DENMARK (DK) 2022-10-27 US disclosed
WO-2022182982-A1 METHODS FOR TREATING C-KIT KINASE MEDIATED DISEASES AND DISORDERS USING A SELECTIVE C-KIT KINASE INHIBITOR THIRD HARMONIC BIO, INC. (US) 2022-09-01 WO disclosed
EP-3982922-A1 DISSACHARIDE FORMULATIONS FOR CONTROLLED DRUG RELEASE Technical University of Denmark (DK) 2022-04-20 EP disclosed
WO-2022040246-A1 IMMUNE MODULATION OF MYELOID DERIVED SUPPRESSIVE CELL FUNCTION FOR CANCER TREATMENT STIMIT CORPORATION (US) 2022-02-24 WO disclosed
WO-2007089069-A1 PHENYL IMIDAZOL SULFONAMIDE DERIVATIVES, THE PREPARATION METHOD THEREOF AND THE WHITENING COSMETIC COMPOSITION CONTAINING THE SAME AMOREPACIFIC CORPORATION (KR) 2007-08-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250295659-A1 METHODS FOR TREATING TRAUMATIC BRAIN INJURY CTTN, SRC, FYN CYP3A4 4839/4885CYP2D6 4871/4885PSEN1 1852/4885
US-20220339285-A1 DISSACHARIDE FORMULATIONS FOR CONTROLLED DRUG RELEASE LIPA, LIPE, CEL CYP3A4 1097/4885CYP2D6 557/4885PSEN1 4803/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.