Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5315962 | 0.79 | GPR35 (0.43) | NSD2SIRT2JAK2JAK3 | |
| SCHEMBL5317201 | 0.78 | HTT (0.49) | MEN1KMT2APKMMAPTALDH1A1 | |
| SCHEMBL4303251 | 0.78 | JAK2 (0.37) | CYP11B1CYP11B2GAAMAPTEGLN2 | |
| SCHEMBL19442277 | 0.77 | PDK2 (0.37) | CYP11B1NSD2FFAR1FFAR4LMNA | |
| SCHEMBL18146732 | 0.76 | TRPA1 (0.36) | MEN1KMT2ACYP11B1CYP11B2NSD2 | |
| SCHEMBL18160359 | 0.74 | CYP11B1 (0.43) | CYP11B1ALDH1A1L3MBTL1 | |
| SCHEMBL18146859 | 0.74 | CYP11B1 (0.43) | CYP11B1ALDH1A1L3MBTL1 | |
| SCHEMBL5317092 | 0.73 | CHRNB2 (0.49) | KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL19440683 | 0.73 | MEN1 (0.51) | MEN1KMT2AMAPTALDH1A1L3MBTL1 | |
| SCHEMBL19996895 | 0.73 | CYP11B1 (0.38) | MEN1KMT2ACYP11B1CYP11B2NSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | claimed |
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | disclosed |