Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7520362 | 0.89 | MAPT (0.50) | NPC1MAPK1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL19659475 | 0.87 | PKM (0.47) | MAPK1ALDH1A1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL19643784 | 0.87 | PKM (0.47) | MAPK1ALDH1A1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL22773415 | 0.84 | LMNA (0.46) | NPC1MAOAMAOBALDH1A1LMNA | |
| SCHEMBL17402270 | 0.82 | CES2 (0.48) | ALDH1A1RAB9ASMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL13182705 | 0.81 | HPGD (0.62) | NPC1MAOAMAOBALDH1A1RAB9A | |
| SCHEMBL11597542 | 0.78 | PPARG (0.51) | ALDH1A1LMNARAB9ANFKB1CYP1A2 | |
| SCHEMBL11596837 | 0.77 | PPARA (0.50) | ALDH1A1LMNARAB9ANFKB1CYP1A2 | |
| SCHEMBL5825596 | 0.75 | KMT2A (0.53) | NPC1MAOBRXRARXRBLMNA | |
| SCHEMBL5824496 | 0.74 | DRD4 (0.50) | NPC1MAOBRAB9ASMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007098090-A2 | TREATMENT OF HYPERPROLIFERATIVE DISEASES WITH N-OXIDES OF ESTROGEN RECEPTOR MODULATORS | NOVACEA, INC. (US) | 2007-08-30 | — | — | WO | disclosed |