SCHEMBL5319409

SCHEMBL5319409

CC(C)C[C@H](C(=O)N1CCNC[C@@]1(C)c1cccc(Cl)c1)[C@H](O)C(=O)NO

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 6/20 0.41
MMP1 P03956 3/20 0.41
MMP8 P22894 3/20 0.41
ADAM17 P78536 1/20 0.40
ANPEP P15144 3/20 0.36
LTA4H P09960 2/20 0.36
MMP9 P14780 3/20 0.33
MMP3 P08254 2/20 0.33
MMP7 P09237 2/20 0.33
LAP3 P28838 1/20 0.33
NPEPPS P55786 1/20 0.33
ERAP2 Q6P179 1/20 0.33
ERAP1 Q9NZ08 1/20 0.33
CTSL P07711 1/20 0.33
CTSB P07858 1/20 0.33
CTSK P43235 1/20 0.33
CHRNA1 P02708 1/20 0.32
CHRNG P07510 1/20 0.32
CHRNB1 P11230 1/20 0.32
CHRNB2 P17787 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5316333 0.91 ADAM17 (0.38) ADAM17CTSLCTSBCTSKCHRNA1
SCHEMBL5323550 0.89 MMP2 (0.44) MMP2MMP1MMP8ANPEPLTA4H
SCHEMBL5325380 0.88 ANPEP (0.40) MMP2MMP1MMP8ADAM17ANPEP
SCHEMBL5318795 0.85 MMP2 (0.38) MMP2MMP1MMP8ADAM17ANPEP
SCHEMBL5317832 0.84 MMP2 (0.40) MMP2MMP1MMP8ADAM17ANPEP
SCHEMBL5373840 0.84 MMP2 (0.37) MMP2MMP1MMP8ADAM17ANPEP
SCHEMBL5341776 0.82 MMP1 (0.40) MMP2MMP1MMP8ANPEPLTA4H
SCHEMBL5320062 0.82 MMP2 (0.43) MMP2MMP1MMP8ADAM17ANPEP
SCHEMBL5319634 0.82 MMP2 (0.43) MMP2MMP1MMP8ADAM17ANPEP
SCHEMBL5403527 0.82 MMP2 (0.43) MMP2MMP1MMP8ADAM17ANPEP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1771421-A1 N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF Applied Research Systems ARS Holding N.V. (AN) 2007-04-11 EP claimed
WO-2006010751-A1 N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) 2006-02-02 WO claimed
EP-1771421-A1 N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF Applied Research Systems ARS Holding N.V. (AN) 2007-04-11 EP disclosed
WO-2006010751-A1 N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) 2006-02-02 WO disclosed