Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 6/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.50 |
| ▸ | LDHA | P00338 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5318214 | 0.90 | PIK3CG (0.62) | PIK3CGPIK3CAKDM4EMAPTRAB9A | |
| SCHEMBL4880949 | 0.82 | PIK3CG (0.69) | PIK3CGPIK3CAKDM4EMAPTRAB9A | |
| SCHEMBL5320437 | 0.80 | IMPDH2 (0.57) | IMPDH2FLT1FLT4KDR | |
| SCHEMBL5316833 | 0.79 | IMPDH2 (0.54) | KDM4EMAPTRAB9AALDH1A1NPC1 | |
| SCHEMBL1651874 | 0.75 | PIK3CG (1.00) | PIK3CGPIK3CAKDM4EMAPTRAB9A | |
| SCHEMBL5334357 | 0.74 | KDR (0.69) | IMPDH2FLT1FLT4KDR | |
| SCHEMBL14466975 | 0.74 | KDR (0.60) | IMPDH2FLT1FLT4KDR | |
| SCHEMBL5318419 | 0.71 | KDR (0.56) | IMPDH2FLT1FLT4KDR | |
| SCHEMBL1651188 | 0.71 | PIK3CG (0.80) | PIK3CGPIK3CARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL5319681 | 0.70 | VCP (0.65) | IMPDH2FLT1FLT4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |