Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 3/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.46 |
| ▸ | DRD2 | P14416 | 11/20 | 0.46 |
| ▸ | DRD1 | P21728 | 11/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA6 | P23280 | 1/20 | 0.45 |
| ▸ | DRD5 | P21918 | 9/20 | 0.45 |
| ▸ | DRD3 | P35462 | 9/20 | 0.45 |
| ▸ | DRD4 | P21917 | 7/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5269525 | 0.89 | HSD17B1 (0.50) | HSD17B1CYP1A2ESR1ESR2DRD2 | |
| SCHEMBL5030308 | 0.89 | HSD17B1 (0.50) | HSD17B1CYP1A2ESR1ESR2DRD2 | |
| SCHEMBL14007352 | 0.84 | CYP1A2 (0.48) | CYP1A2ESR1ESR2DRD2DRD1 | |
| SCHEMBL29439100 | 0.83 | HSD17B1 (0.64) | HSD17B1ESR1ESR2DRD2DRD1 | |
| SCHEMBL30924248 | 0.83 | MEN1 (0.46) | CYP1A2CA1CA2MAOAMAOB | |
| SCHEMBL1655232 | 0.83 | MEN1 (0.46) | CYP1A2CA1CA2MAOAMAOB | |
| SCHEMBL788852 | 0.83 | HSD17B1 (0.64) | HSD17B1ESR1ESR2DRD2DRD1 | |
| SCHEMBL25940944 | 0.82 | CYP1A2 (0.47) | CYP1A2ESR1ESR2DRD2DRD1 | |
| SCHEMBL217399 | 0.82 | KDM4E (0.59) | HSD17B1CYP1A2ESR1ESR2DRD2 | |
| SCHEMBL29373696 | 0.82 | KDM4E (0.59) | HSD17B1CYP1A2ESR1ESR2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272471-B1 | NON-STEROIDAL, TETRACYCLIC COMPOUNDS FOR ESTROGEN-RELATED TREATMENTS | ORGANON NV (NL) | 2007-10-03 | — | — | EP | disclosed |
| US-20030144313-A1 | Non-steroidal, tetracylic compounds for estrogen-related treatments | N.V. ORGANON (NL) | 2003-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030144313-A1 | Non-steroidal, tetracylic compounds for estrogen-related treatments | ESRRA, ESRRB, ESRRG | HSD17B1 61/4885CYP1A2 302/4885ESR1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.