Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 6/20 | 0.60 |
| ▸ | KDR | P35968 | 12/20 | 0.60 |
| ▸ | FLT1 | P17948 | 9/20 | 0.60 |
| ▸ | FLT4 | P35916 | 9/20 | 0.60 |
| ▸ | VCP | P55072 | 1/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.51 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14466975 | 0.90 | KDR (0.60) | IMPDH2KDRFLT1FLT4VCP | |
| SCHEMBL5318254 | 0.88 | VCP (0.58) | IMPDH2KDRFLT1FLT4VCP | |
| SCHEMBL5319618 | 0.81 | FLT1 (0.59) | IMPDH2KDRFLT1FLT4VCP | |
| SCHEMBL5316983 | 0.78 | VCP (0.58) | IMPDH2KDRFLT1FLT4VCP | |
| SCHEMBL4876627 | 0.76 | TSHR (0.59) | KDRRIPK2EGFRTGFBR1RIPK3 | |
| SCHEMBL24588180 | 0.76 | RIPK2 (0.56) | KDRRIPK2EGFRTGFBR1RIPK3 | |
| Gw549390X SCHEMBL3295009 | 0.76 | KDR (1.00) | IMPDH2KDRFLT1FLT4VCP | |
| SCHEMBL5319636 | 0.75 | IMPDH2 (0.60) | IMPDH2KDRFLT1FLT4VCP | |
| SCHEMBL5340017 | 0.75 | IMPDH2 (0.60) | IMPDH2KDRFLT1FLT4VCP | |
| SCHEMBL5502826 | 0.75 | IMPDH2 (0.68) | IMPDH2KDRFLT1FLT4VCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |