SCHEMBL5319903

SCHEMBL5319903

Cc1cc(O)ccc1Oc1cc(Cl)ncn1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAF1 P04049 3/20 0.42
MAPT P10636 2/20 0.39
MAPK1 P28482 2/20 0.39
NPC1 O15118 1/20 0.39
ALDH1A1 P00352 1/20 0.39
LMNA P02545 1/20 0.39
HSP90AA1 P07900 1/20 0.39
XBP1 P17861 1/20 0.39
HTT P42858 1/20 0.39
RAB9A P51151 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
S1PR1 P21453 2/20 0.39
KDR P35968 6/20 0.38
BRAF P15056 2/20 0.38
MAPK14 Q16539 1/20 0.37
POLB P06746 1/20 0.36
CYP3A4 P08684 2/20 0.36
CHRM1 P11229 1/20 0.36
ALOX15 P16050 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27423552 0.80 SMN1; SMN2 (0.56) RAF1MAPTMAPK1NPC1ALDH1A1
SCHEMBL5319900 0.79 RAF1 (0.39) RAF1MAPTMAPK1NPC1ALDH1A1
SCHEMBL20605406 0.77 ALDH1A1 (0.45) MAPTMAPK1NPC1ALDH1A1LMNA
SCHEMBL15490439 0.75 SMN1; SMN2 (0.41) RAF1MAPTMAPK1NPC1ALDH1A1
SCHEMBL5032967 0.74 CYP3A4 (0.44) CYP3A4CHRM1ALOX15MAOATBXA2R
SCHEMBL22567997 0.73 GAA (0.43) MAPTMAPK1NPC1ALDH1A1LMNA
SCHEMBL3180657 0.73 RAF1 (0.50) RAF1MAPTNPC1ALDH1A1LMNA
SCHEMBL5317250 0.73 ACHE (0.50) MAPTMAPK1NPC1ALDH1A1LMNA
SCHEMBL5316491 0.73 MET (0.37) MAPTLMNAHSP90AA1CHRM1TBXA2R
SCHEMBL7131517 0.73 CYP1A2 (0.40) RAF1MAPTMAPK1NPC1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007079173-A2 NOVEL 2-HETEROARYLOXY-PHENOL DERIVATIVES AS ANTIBACTERIAL AGENTS EMERGENT BIOSOLUTIONS INC. (US) 2007-07-12 WO disclosed