Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTH1R | Q03431 | 2/20 | 0.43 |
| ▸ | PTGIR | P43119 | 8/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 5/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGAV | P06756 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
| ▸ | CCKBR | P32239 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5320137 | 0.73 | PTH1R (0.72) | PTH1RCCKBR | |
| SCHEMBL5321430 | 0.67 | CYP19A1 (0.36) | PTH1RCCKBR | |
| SCHEMBL5320787 | 0.61 | PTH1R (1.00) | PTH1RPTGIRCCKBR | |
| SCHEMBL6829822 | 0.60 | CCKBR (0.40) | PTH1RCCKBR | |
| SCHEMBL14566393 | 0.60 | PTH1R (0.79) | PTH1R | |
| SCHEMBL5494976 | 0.59 | PTH1R (0.84) | PTH1RPTGIRADRA2AADRA2BADRA2C | |
| SCHEMBL5281350 | 0.59 | PTH1R (0.38) | PTH1RPDE4DCCKBR | |
| SCHEMBL5287497 | 0.59 | PTH1R (0.50) | PTH1RPDE4D | |
| SCHEMBL3909395 | 0.58 | PDE4A (0.45) | PDE4DCCKBR | |
| SCHEMBL9178572 | 0.58 | NISCH (0.46) | PTH1RADRA2AADRA2BADRA2CADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006129120-A9 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2007-03-22 | — | — | WO | disclosed |
| WO-2006129120-A2 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2006-12-07 | — | — | WO | disclosed |