SCHEMBL5320282

SCHEMBL5320282

CC(=O)CC(Cl)c1cccc(Cl)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.48
KMT2A Q03164 1/20 0.48
ALDH1A1 P00352 1/20 0.44
HPGD P15428 1/20 0.44
ACP3 P15309 1/20 0.42
CACNA1G O43497 1/20 0.41
CACNA2D1 P54289 1/20 0.41
CACNA1B Q00975 1/20 0.41
CACNB1 Q02641 1/20 0.41
CACNA1C Q13936 1/20 0.41
NPSR1 Q6W5P4 1/20 0.40
TACR1 P25103 1/20 0.39
ADRB2 P07550 1/20 0.39
ADRB1 P08588 1/20 0.39
ADRB3 P13945 1/20 0.39
FFAR1 O14842 1/20 0.39
ADRA1D P25100 1/20 0.39
AOC3 Q16853 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2C9 P11712 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16788643 0.83 L3MBTL1 (0.49) MEN1KMT2AALDH1A1HPGDADRB2
SCHEMBL15590888 0.83 L3MBTL1 (0.49) MEN1KMT2AALDH1A1HPGDADRB2
SCHEMBL17857555 0.81 KMT2A (0.47) MEN1KMT2AALDH1A1HPGDACP3
SCHEMBL4729080 0.80 ALDH1A1 (0.50) MEN1KMT2AALDH1A1HPGDTACR1
SCHEMBL23750201 0.79 GABBR2 (0.47) MEN1KMT2AALDH1A1HPGDACP3
SCHEMBL12861282 0.79 OPRM1 (0.49) MEN1KMT2AALDH1A1HPGDAOC3
SCHEMBL23750165 0.79 GABBR2 (0.47) MEN1KMT2AALDH1A1HPGDACP3
SCHEMBL5321358 0.78 BRD4 (0.50) MEN1KMT2AFFAR1CYP1A2CYP2C9
SCHEMBL5820379 0.77 ACP3 (0.46) MEN1KMT2AALDH1A1ACP3ADRB2
SCHEMBL5032818 0.77 ACP3 (0.46) MEN1KMT2AALDH1A1ACP3ADRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007095756-A1 NOVEL CENTRAL-NERVOUS SYSTEM ACTING COMPOUNDS AND METHODS FOR THE TREATMENT OF CNS DISORDERS CLERA INC. (CA) 2007-08-30 WO disclosed