Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.35 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.35 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | CTSG | P08311 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 2/20 | 0.33 |
| ▸ | DBH | P09172 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.32 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.32 |
| ▸ | APAF1 | O14727 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2345172 | 0.87 | KDM4E (0.44) | PRKCIGABRA1GABRB2ERCC1ERCC4 | |
| SCHEMBL5319151 | 0.81 | TYR (0.44) | PRKCIGABRA1GABRB2ALOX15ALOX12 | |
| SCHEMBL5317566 | 0.80 | PRKCI (0.36) | PRKCIGABRA1GABRB2ERCC1ERCC4 | |
| SCHEMBL6248807 | 0.79 | ALOX15 (0.40) | PRKCIGABRA1GABRB2ERCC1ERCC4 | |
| SCHEMBL6247141 | 0.76 | PRKCI (0.46) | PRKCIGABRA1GABRB2ALOX15ALOX12 | |
| SCHEMBL5202172 | 0.75 | ERCC1 (0.41) | PRKCIERCC1ERCC4GAAPOLB | |
| SCHEMBL6245897 | 0.72 | TYR (0.50) | ALOX15MAPTCYP3A4TYR | |
| SCHEMBL15942178 | 0.72 | AKR1B1 (0.48) | GABRA1GABRB2KDM4ERECQLAPAF1 | |
| SCHEMBL21400207 | 0.71 | GAA (0.51) | ALOX15GAAL3MBTL1CYP3A4MAPK1 | |
| SCHEMBL1923014 | 0.71 | GAA (0.51) | ALOX15GAAL3MBTL1CYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773774-A2 | HETEROCYCLIC ACETOPHENONE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merck & Co., Inc. (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006014918-A2 | HETEROCYCLIC ACETOPHENONE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERCK & CO., INC. (US) | 2006-02-09 | — | — | WO | disclosed |