Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 1/20 | 0.41 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
| ▸ | IAPP | P10997 | 1/20 | 0.37 |
| ▸ | SHBG | P04278 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL660344 | 0.84 | IAPP (0.46) | PRKCIIAPP | |
| SCHEMBL9130849 | 0.82 | IAPP (0.44) | PRKCIIAPP | |
| SCHEMBL5201499 | 0.78 | TYR (0.49) | PRKCIIAPPSHBGCYP3A4PKM | |
| SCHEMBL11049780 | 0.78 | KMT2A (0.50) | CA2PKMLMNAGAAMAPT | |
| SCHEMBL5320901 | 0.75 | PRKCI (0.36) | ERCC1ERCC4PRKCICYP3A4MAPK1 | |
| SCHEMBL31013617 | 0.72 | IAPP (0.67) | IAPPCA2L3MBTL1LMNA | |
| SCHEMBL1426061 | 0.72 | IAPP (0.67) | IAPPCA2L3MBTL1LMNA | |
| SCHEMBL2345172 | 0.72 | KDM4E (0.44) | ERCC1ERCC4PRKCIL3MBTL1POLB | |
| SCHEMBL31514651 | 0.72 | GPR35 (0.40) | PRKCIMAPK1 | |
| SCHEMBL14370499 | 0.71 | ERCC1 (0.45) | ERCC1ERCC4PRKCICYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817300-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2007-08-15 | — | — | EP | disclosed |
| EP-1817296-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006057860-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2006-06-01 | — | — | WO | disclosed |
| WO-2006057869-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2006-06-01 | — | — | WO | disclosed |