Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5321750 | 1.00 | OPRK1 (0.49) | OPRK1MAPTALDH1A1LMNAL3MBTL1 | |
| SCHEMBL5321515 | 0.86 | SMN1; SMN2 (0.42) | OPRK1MAPTLMNASMN1; SMN2F10 | |
| SCHEMBL5321509 | 0.86 | SMN1; SMN2 (0.42) | OPRK1MAPTLMNASMN1; SMN2F10 | |
| SCHEMBL5468309 | 0.83 | CNR1 (0.41) | OPRK1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL5469398 | 0.83 | RAB9A (0.41) | OPRK1MAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL5324440 | 0.83 | RAB9A (0.41) | OPRK1MAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL30350660 | 0.75 | L3MBTL1 (0.46) | OPRK1MAPTALDH1A1LMNAL3MBTL1 | |
| SCHEMBL19510704 | 0.75 | L3MBTL1 (0.46) | OPRK1MAPTALDH1A1LMNAL3MBTL1 | |
| SCHEMBL25031455 | 0.72 | LGMN (0.56) | MAPTALDH1A1L3MBTL1SMN1; SMN2POLB | |
| SCHEMBL10629048 | 0.70 | MAPT (0.53) | MAPTALDH1A1LMNAL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007103719-A2 | MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME | INCYTE CORPORATION (US) | 2007-09-13 | — | — | WO | disclosed |