Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | USP7 | Q93009 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | EIF4E | P06730 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.39 |
| ▸ | RHEB | Q15382 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 1/20 | 0.39 |
| ▸ | RARG | P13631 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL364210 | 0.84 | TSHR (0.62) | HPGDLMNAL3MBTL1ALDH1A1TSHR | |
| SCHEMBL835108 | 0.82 | HPGD (1.00) | HPGDLMNAL3MBTL1ALDH1A1MAPT | |
| SCHEMBL1755726 | 0.82 | HPGD (1.00) | HPGDLMNAL3MBTL1ALDH1A1MAPT | |
| SCHEMBL5322959 | 0.81 | HPGD (0.79) | HPGDLMNAL3MBTL1ALDH1A1USP7 | |
| SCHEMBL313211 | 0.78 | TSHR (0.64) | HPGDTSHRMAPTSRD5A2MEN1 | |
| SCHEMBL8478583 | 0.78 | TSHR (0.64) | HPGDTSHRMAPTSRD5A2MEN1 | |
| SCHEMBL29655535 | 0.78 | TSHR (0.64) | HPGDTSHRMAPTSRD5A2MEN1 | |
| SCHEMBL10957865 | 0.78 | HAO1 (0.53) | LMNATSHRMAPTMEN1KMT2A | |
| SCHEMBL678860 | 0.77 | SCN9A (0.68) | HPGDALDH1A1MEN1KMT2A | |
| SCHEMBL30837205 | 0.76 | SCN9A (0.58) | TSHRMAPTSRD5A2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007114916-A2 | ARYLBENZYLPIPERIDINE COMPOUNDS | H. LUNDBECK A/S (DK) | 2007-10-11 | — | — | WO | disclosed |
| US-20070082934-A1 | Substituted 4-aryloxy and 4-arylsulfanyl-phenyl-2-aminothiazoles as inhibitors of cell proliferation | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2007-04-12 | — | — | US | disclosed |
| WO-2005044263-A1 | SUBSTITUTED 4-ARYLOXY AND 4-ARYLSULFANYL-PHENYL-2-AMINOTHIAZOLES AS INHIBITORS OF CELL PROLIFERATION | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2005-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070082934-A1 | Substituted 4-aryloxy and 4-arylsulfanyl-phenyl-2-aminothiazoles as inhibitors of cell proliferation | MKI67, CCNI, CDK4 | HPGD 2433/4885LMNA 4630/4885L3MBTL1 2111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.