SCHEMBL5323575

SCHEMBL5323575

O=C(Oc1ncc[nH]1)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.45
METAP2 P50579 1/20 0.45
METAP1 P53582 1/20 0.45
HDAC6 Q9UBN7 1/20 0.45
ALDH1A1 P00352 4/20 0.44
KDM4E B2RXH2 2/20 0.44
F2 P00734 1/20 0.44
KMT2A Q03164 5/20 0.43
MAPT P10636 5/20 0.43
SMN1; SMN2 Q16637 3/20 0.43
PARP1 P09874 1/20 0.43
HSD17B10 Q99714 1/20 0.43
TSHR P16473 1/20 0.41
TDP1 Q9NUW8 2/20 0.41
PARP10 Q53GL7 1/20 0.41
MEN1 O00255 1/20 0.41
RAB9A P51151 2/20 0.41
GAA P10253 2/20 0.40
L3MBTL1 Q9Y468 1/20 0.39
PKM P14618 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15234294 0.88 KDM4E (0.41) LMNAMETAP2METAP1HDAC6ALDH1A1
SCHEMBL5148448 0.85 ALDH1A1 (0.46) LMNAALDH1A1KDM4EKMT2AMAPT
Water SCHEMBL11231296 0.83 CSNK1A1 (0.44) ALDH1A1KDM4EKMT2AMAPTSMN1; SMN2
SCHEMBL4879110 0.81 ALDH1A1 (0.42) LMNAALDH1A1KDM4EKMT2AMAPT
SCHEMBL24485 0.79 HPGD (0.51) LMNAALDH1A1KDM4EKMT2AMAPT
SCHEMBL10438254 0.78 NPC1 (0.45) LMNAKMT2AMAPTMEN1RAB9A
SCHEMBL667770 0.77
SCHEMBL9364970 0.77 KMT2A (0.54) LMNAALDH1A1KDM4EKMT2AMAPT
SCHEMBL727155 0.77 NPC1 (0.43) ALDH1A1KDM4EKMT2ASMN1; SMN2RAB9A
SCHEMBL11691032 0.76 L3MBTL1 (0.46) LMNAALDH1A1KDM4ESMN1; SMN2TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007114652-A1 NOVEL BENZIMIDAZOLE MONOMERS TERMINATED WITH TRIFLUOROVINYLOXY GROUPS AND POLYBENZIMIDAZOLES MEMBRANE PREPARED BY USING THE SAME MONOMERS KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2007-10-11 WO claimed
WO-2025096494-A1 UBIQUITIN SPECIFIC PROCESSING PROTEASE 1 (USP1) COMPOUNDS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-05-08 WO disclosed
CN-110590742-B N1Long chain alkyl-N3Application of piperidine ethyl imidazole salt 枣庄学院 2022-02-01 CN disclosed
EP-3538088-A1 HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS 3-V Biosciences, Inc. (US) 2019-09-18 EP disclosed
WO-2018089904-A1 HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS 3-V BIOSCIENCES, INC. (US) 2018-05-17 WO disclosed
CN-102695708-B N1-pyrazolospiroketone acetyl-coA carboxylase inhibitors PFIZER INC. (US) 2014-10-15 CN disclosed
CN-102695708-A N1-pyrazolospiroketone acetyl-coA carboxylase inhibitors PFIZER 2012-09-26 CN disclosed
CN-101679432-A Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors SIGNAL PHARM LLC 2010-03-24 CN disclosed
WO-2007114652-A1 NOVEL BENZIMIDAZOLE MONOMERS TERMINATED WITH TRIFLUOROVINYLOXY GROUPS AND POLYBENZIMIDAZOLES MEMBRANE PREPARED BY USING THE SAME MONOMERS KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2007-10-11 WO disclosed
CN-1976932-A Fused quinoline derivative and use thereof TAKEDA PHARMACEUTICAL (JP) 2007-06-06 CN disclosed
CN-1759095-A N,N'-substituted-1,3-diamino-2-hydroxypropane derivatives ELAN PHARM INC (US) 2006-04-12 CN disclosed
CN-1221529-C Substituted N- [ (aminoiminomethyl or aminomethyl) phenyl ] propyl amides ARVENTIS PHARMACEUTICALS INC (US) 2005-10-05 CN disclosed
CN-1441783-A Drug containing dicyanopyridine derivative YAMANOUCHI PHARMA CO LTD (JP) 2003-09-10 CN disclosed
CN-1236358-A Substituted N-[(aminoiminomethyl or aminomethyl) phenyl] propyl amides RHONE POULENC RORER PHARMA (US) 1999-11-24 CN disclosed
US-4874747-A DERMATOLOGY CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (CIRD) (FR) 1989-10-17 US disclosed