Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5280440 | 0.89 | SLC7A5 (0.48) | SLC7A5HRH1TAAR1SLC6A4SLC6A2 | |
| SCHEMBL5286697 | 0.84 | TAAR1 (0.39) | SLC7A5TAAR1SLC6A4LTA4HPOLB | |
| SCHEMBL11065085 | 0.84 | PPARG (0.44) | SLC7A5SLC6A4ALDH1A1PPARGPPARA | |
| SCHEMBL20449085 | 0.84 | TAAR1 (0.39) | SLC7A5TAAR1SLC6A4LTA4HPOLB | |
| SCHEMBL7960172 | 0.83 | TSHR (0.42) | SLC6A4ALDH1A1PPARGPPARALTA4H | |
| SCHEMBL28036217 | 0.81 | HRH1 (0.42) | SLC7A5HRH1TAAR1SLC6A4SLC6A2 | |
| SCHEMBL10933718 | 0.81 | SLC6A4 (0.39) | SLC7A5SLC6A4ALDH1A1PPARGPPARA | |
| SCHEMBL20169585 | 0.81 | SLC6A4 (0.39) | SLC7A5SLC6A4ALDH1A1PPARGPPARA | |
| SCHEMBL27438936 | 0.81 | LTA4H (0.44) | SLC7A5SLC6A4ALDH1A1PPARGPPARA | |
| Methyl Alcohol SCHEMBL11163562 | 0.81 | ALDH1A1 (0.40) | SLC7A5TAAR1ALDH1A1PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2847174-A1 | PYRIMIDINONE CARBOXAMIDES AS INHIBITORS OF ENDOTHELIAL LIPASE | Bristol-Myers Squibb Company (US) | 2015-03-18 | — | — | EP | disclosed |
| WO-2013151923-A1 | PYRIMIDINONE CARBOXAMIDES AS INHIBITORS OF ENDOTHELIAL LIPASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-10-10 | — | — | WO | disclosed |
| EP-1756107-A2 | ARYL-SUBSTITUTED PIPERAZINE DERIVATIVES | NEUROGEN CORPORATION (US) | 2007-02-28 | — | — | EP | disclosed |
| WO-2006009789-A2 | ARYL-SUBSTITUTED PIPERAZINE DERIVATIVES | NEUROGEN CORPORATION (US) | 2006-01-26 | — | — | WO | disclosed |