Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.33 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.32 |
| ▸ | SRC | P12931 | 2/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbamic Acid SCHEMBL14813023 | 0.75 | FGFR1 (0.36) | HSD17B10MAPTFGFR1FGFR2FGFR4 | |
| Bicarbonate SCHEMBL27878739 | 0.75 | ALDH1A1 (0.38) | HSP90AA1HSP90AB1ALDH1A1FGFR1FGFR2 | |
| SCHEMBL737866 | 0.72 | MAOA (0.41) | HSD17B10NPC1RAB9AALDH1A1MAOA | |
| SCHEMBL19188983 | 0.71 | ALDH1A1 (0.39) | NPC1RAB9AALDH1A1MAOANOTUM | |
| Formaldehyde SCHEMBL27547732 | 0.69 | MAOA (0.38) | HSD17B10NPC1RAB9AALDH1A1MAOA | |
| SCHEMBL5393525 | 0.68 | — | — | |
| SCHEMBL7003679 | 0.66 | MEN1 (0.46) | HSD17B10NPC1RAB9AALDH1A1MAOA | |
| SCHEMBL27910961 | 0.66 | ALDH1A1 (0.38) | ALDH1A1 | |
| Acetic Acid SCHEMBL7042249 | 0.63 | MAOA (0.40) | HSP90AA1HSP90AB1NPC1RAB9AALDH1A1 | |
| Acetic Acid SCHEMBL11385294 | 0.62 | CES2 (0.50) | HSP90AA1HSP90AB1NAPRTHSD17B10NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1868653-A2 | HMGCOA REDUCTASE INHIBITOR CODRUGS AND USES THEREOF | PSivida Inc. (US) | 2007-12-26 | — | — | EP | disclosed |
| EP-1811958-A2 | REMOVAL OF IMPURITIES WITH SUPERCRITICAL FLUIDS FROM OCULAR DRUG DELIVERY DEVICES DURING MANUFACTURING | Bausch & Lomb Incorporated (US) | 2007-08-01 | — | — | EP | disclosed |
| EP-1761283-A2 | BIODEGRADABLE DRUG-POLYMER DELIVERY SYSTEM | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2007-03-14 | — | — | EP | disclosed |
| WO-2007002183-A2 | DRUG DELIVERY DEVICE FOR IMPLANTING IN THE EYE COMPRISING A DRUG CORE AND A PREFORMED PERMEABLE CRYSTALLINE POLYMERIC DISC | BAUSCH & LOMB INCORPORATED (US) | 2007-01-04 | — | — | WO | disclosed |
| WO-2006110882-A2 | HMGCOA REDUCTASE INHIBITOR CODRUGS AND USES THEREOF | PSIVIDA INC. (US) | 2006-10-19 | — | — | WO | disclosed |
| EP-1699393-A2 | DRUG DELIVERY DEVICE WITH MECHANICAL LOCKING MECHANISM | Bausch & Lomb Incorporated (US) | 2006-09-13 | — | — | EP | disclosed |
| EP-1699392-A2 | DRUG DELIVERY DEVICE | Bausch & Lomb Incorporated (US) | 2006-09-13 | — | — | EP | disclosed |
| EP-1696880-A2 | DRUG DELIVERY DEVICE WITH SUTURE RING | Bausch & Lomb Surgical, Inc. (US) | 2006-09-06 | — | — | EP | disclosed |
| EP-1696879-A2 | DRUG DELIVERY DEVICE | BAUSCH & LOMB INCORPORATED (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2006068950-A2 | DRUG DELIVERY DEVICE COMPRISING CROSSLINKED POLYURETHANE-SILOXANE-CONTAINING COPOLYMERS | BAUSCH & LOMB INCORPORATED (US) | 2006-06-29 | — | — | WO | disclosed |
| WO-2005120578-A2 | BIODEGRADABLE DRUG-POLYMER DELIVERY SYSTEM | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2005-12-22 | — | — | WO | disclosed |
| WO-2005065642-A2 | DRUG DELIVERY DEVICE | BAUSCH & LOMB INCORPORATED (US) | 2005-07-21 | — | — | WO | disclosed |
| WO-2005065602-A2 | DRUG DELIVERY DEVICE WITH MECHANICAL LOCKING MECHANISM | BAUSCH & LOMB INCORPORATED (US) | 2005-07-21 | — | — | WO | disclosed |
| WO-2005065601-A2 | DRUG DELIVERY DEVICE | BAUSCH & LOMB INCORPORATED (US) | 2005-07-21 | — | — | WO | disclosed |
| WO-2005065644-A2 | DRUG DELIVERY DEVICE WITH MESH BASED SUTURE TAB | BAUSCH & LOMB INCORPORATED (US) | 2005-07-21 | — | — | WO | disclosed |
| WO-2005063204-A2 | DRUG DELIVERY DEVICE WITH SUTURE RING | BAUSCH & LOMB INCORPORATED (US) | 2005-07-14 | — | — | WO | disclosed |
| WO-2005004841-A1 | DRUG DELIVERY DEVICE | BAUSCH & LOMB INCORPORATED (US) | 2005-01-20 | — | — | WO | disclosed |
| WO-2004064839-A1 | SALTS OF CODRUGS OF AN OPIOID TOGETHER WITH A SECOND ACTIVE MOIETY AND USES THERETO | CONTROL DELIVERY SYSTEMS, INC. (US) | 2004-08-05 | — | — | WO | disclosed |
| EP-1404295-A2 | SUSTAINED RELEASE DRUG DELIVERY DEVICES WITH COATED DRUG CORES | BAUSCH & LOMB INCORPORATED (US) | 2004-04-07 | — | — | EP | disclosed |
| WO-2002053130-A2 | SUSTAINED RELEASE DRUG DELIVERY DEVICES WITH COATED DRUG CORES | BAUSCH & LOMB INCORPORATED (US) | 2002-07-11 | — | — | WO | disclosed |