Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | STK10 | O94804 | 7/20 | 0.37 |
| ▸ | SLK | Q9H2G2 | 7/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | PRKCB | P05771 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5158690 | 0.88 | DPP4 (0.46) | DPP4CHEK1STK10SLKHSD17B10 | |
| SCHEMBL1996958 | 0.69 | DPP4 (0.46) | DPP4HSD17B10ALDH1A1GAAKDM4E | |
| SCHEMBL3149112 | 0.68 | DPP4 (0.45) | DPP4CHEK1NPC1HSD17B10ALDH1A1 | |
| SCHEMBL1993654 | 0.68 | DPP4 (0.45) | DPP4CHEK1NPC1ALDH1A1KDM4E | |
| SCHEMBL3149462 | 0.65 | DPP4 (0.57) | DPP4HSD17B10ALDH1A1GSK3B | |
| SCHEMBL6867119 | 0.65 | TAAR1 (0.55) | DPP4HSD17B10ALDH1A1GAA | |
| SCHEMBL18170650 | 0.63 | ADORA2A (0.54) | CHEK1STK10SLKALDH1A1GSK3B | |
| SCHEMBL4139350 | 0.62 | IL6 (0.39) | CHEK1STK10SLKHSD17B10ALDH1A1 | |
| SCHEMBL23611757 | 0.62 | HSD17B10 (0.66) | NPC1HSD17B10ALDH1A1GAAGSK3B | |
| SCHEMBL3143679 | 0.62 | DPP4 (1.00) | DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007112347-A1 | DIPEPTIDYL PEPTIDASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-10-04 | — | — | WO | claimed |
| WO-2007112347-A1 | DIPEPTIDYL PEPTIDASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-10-04 | — | — | WO | disclosed |